{"id":54154,"date":"2018-03-09T22:41:52","date_gmt":"2018-03-09T22:41:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-de-marcadores-para-diagnostico-diferencial-y-potenciales-dianas-terapeuticas-en-adenocarcinoma-ductal-de-pancreas-mediante-herramientas-genomicas\/"},"modified":"2018-03-09T22:41:52","modified_gmt":"2018-03-09T22:41:52","slug":"identificacion-de-marcadores-para-diagnostico-diferencial-y-potenciales-dianas-terapeuticas-en-adenocarcinoma-ductal-de-pancreas-mediante-herramientas-genomicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica\/identificacion-de-marcadores-para-diagnostico-diferencial-y-potenciales-dianas-terapeuticas-en-adenocarcinoma-ductal-de-pancreas-mediante-herramientas-genomicas\/","title":{"rendered":"Identificaci\u00f3n de marcadores para diagn\u00f3stico diferencial y potenciales dianas terap\u00e9uticas en adenocarcinoma ductal de p\u00e1ncreas mediante herramientas gen\u00f3micas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Amo Iribarren Joaquin Del <\/strong><\/h2>\n<p>A pesar de los avances en diagn\u00f3stico y terapia, el c\u00e1ncer de p\u00e1ncreas (pdac) contin\u00faa siendo el de pero pron\u00f3stico de todos los tumores s\u00f3lidos malignos. Durante el trabajo realizado en esta tesis doctoral, se llev\u00f3 a cabo un an\u00e1lisis global de expresi\u00f3n g\u00e9nica en biopsias de pdac, p\u00e1ncreas normal y pancreatitis cr\u00f3nica mediante microarrays de oligonucle\u00f3tidos. Se identificaron transcritos diferencialmente expresados usando herramientas bioinform\u00e1ticas, entre los cu\u00e1les, se seleccionaron 116 genes sobre-expresados en pdac. Esta lista de genes se orden\u00f3 bajo un sistema de propiedad, teniendo en cuenta datos experimentales y bibliogr\u00e1ficos. La expresi\u00f3n de 34 de estos genes se analz\u00f3mediante re-pcr cuantitativa a tiempo real para validar el resultado del microarray. Se clonaron y expresaron 10 de las prote\u00ednas codificadas por los genes diana y se generaron anticuerpos policlonales contra dos de ellas. Cinco de las prote\u00ednas codificadas por los genes identificados y validados por q-rt-pcr, se detectaron tambi\u00e9n a mayor nivel en biopsias de pdac respecto a los controles, mediante western-blotting. As\u00ed mismo, se evalu\u00f3 el inter\u00e9s de algunos de estos anticuerpos como marcadores de diagn\u00f3stico diferencial el pdac mediante inmunohistoqu\u00edmic. Mediante una colaboraci\u00f3n, se desarroll\u00f3 un modelo animal de adenocarcinoma ductal de p\u00e1ncreas que reprodujo en cuanto a anatom\u00eda e histolog\u00eda las caracter\u00edsticas del pdac humano. Adem\u00e1s se confirm\u00f3 que los tumores de p\u00e1ncreas desarrollados por xenotrasplante en rat\u00f3n, expresaban algunas de las dianas identificadas en las biopsias de pdac humano, lo que permitir\u00e1 ensayar, in vivo, terapias dirigidas contra los genes y prote\u00ednas identificadas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificaci\u00f3n de marcadores para diagn\u00f3stico diferencial y potenciales dianas terap\u00e9uticas en adenocarcinoma ductal de p\u00e1ncreas mediante herramientas gen\u00f3micas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificaci\u00f3n de marcadores para diagn\u00f3stico diferencial y potenciales dianas terap\u00e9uticas en adenocarcinoma ductal de p\u00e1ncreas mediante herramientas gen\u00f3micas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Amo Iribarren Joaquin Del <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gorka Ochoa Garay<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Fernandez piqueras <\/li>\n<li> Toyos gonz\u00e1lez Juan  ram\u00f3n de los (vocal)<\/li>\n<li>Francisco xavier Real arribas (vocal)<\/li>\n<li> Castrillo diez Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Amo Iribarren Joaquin Del A pesar de los avances en diagn\u00f3stico y terapia, el c\u00e1ncer de p\u00e1ncreas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,8901,962,12909],"tags":[119564,17609,13679,119565,14602,116006],"class_list":["post-54154","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-carcinogenesis","category-genetica","category-pais-vasco-euskal-herriko-unibertsitatea","tag-amo-iribarren-joaquin-del","tag-castrillo-diez-jose-luis","tag-francisco-xavier-real-arribas","tag-gorka-ochoa-garay","tag-jose-fernandez-piqueras","tag-toyos-gonzalez-juan-ramon-de-los"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=54154"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54154\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=54154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=54154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=54154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}