{"id":54187,"date":"2018-03-09T22:41:52","date_gmt":"2018-03-09T22:41:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-molecular-de-los-sarcomas-de-partes-blandas-deteccion-de-la-enfermedad-ma%c2%adnima-residual\/"},"modified":"2018-03-09T22:41:52","modified_gmt":"2018-03-09T22:41:52","slug":"caracterizacion-molecular-de-los-sarcomas-de-partes-blandas-deteccion-de-la-enfermedad-ma%c2%adnima-residual","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pediatria\/caracterizacion-molecular-de-los-sarcomas-de-partes-blandas-deteccion-de-la-enfermedad-ma%c2%adnima-residual\/","title":{"rendered":"Caracterizaci\u00f3n molecular de los sarcomas de partes blandas. detecci\u00f3n de la enfermedad m\u00ednima residual"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anna Llort Sales <\/strong><\/h2>\n<p>Los sarcomas de partes blandas son el tercer grupo de neoplaisas m\u00e1s frecuente durante la edad pedi\u00e1trica. El sarcoma de ewing (se) y el rabadomiosarcoma rms) forman parte de este grupo. La presencia de enfermedad micrometast\u00e1sica al diagn\u00f3stico y de enfermedad m\u00ednima residual durante el seguimiento de los pacientes afectos de neoplasias malignas ha demostrado ser un factor pron\u00f3stico de riesgo de reca\u00edda de  pacientes con leucemias y otras neoplasias s\u00f3lidadas epiteliales del adulto. En la edad pedi\u00e1trica hay algunas evidencias sugiriendo que en los sarcomas de partes blandas, el seguimiento de la enfermedad residual puede constituir un par\u00e1metro pron\u00f3stico adicional.  objetivos     determinar y cuantificar la presencia de la enfermedad micromestat\u00e1sica y microcirculante en los pacientes pedi\u00e1tricos afectos de sarcomas de partes blandas. Determinar el impacto pron\u00f3stico de la detecci\u00f3n de la enfermedad residual m\u00ednima y estudiar la correlaci\u00f3n entre los distintos marcadores.  metodolog\u00eda     se han analizado la presencia de c\u00e9lulas tumorales en sangre perif\u00e9rica (sp) y m\u00e9dula \u00f3sea (mo) mediante el an\u00e1lisis del mrna de genes tejido espec\u00edficos de rabdomisarcomas embrionarios (rach y myod1) y de genes quim\u00e9ricos tumor-espec\u00edficos en rms alveolares (pax3\/7-fkhr) y en se (ews-fli1\/erg), utilizando dos t\u00e9cnicas rt-pcr cualitativa y la rt-pcr en tiempo real.  conclusiones     la utilizaci\u00f3n de m\u00faltiples marcadores para la monitorizaci\u00f3n de la emr permite aumentar la fiabilidad de los resultados, disminuyendo los falsos positivos. El an\u00e1lisis mediante rt-pcr de la expresi\u00f3n de los genes de fusi\u00f3n ews-fli1-erg y pax3\/7-fkhr y de myopd1 y rach en m\u00e9dula \u00f3sea permite incrementar la sensibilidad respecto a la citolog\u00eda conveniconal. La pcr en tiempo real permite la cuantificaci\u00f3n relativa de la presencia de las c\u00e9lulas tumorales. La detecci\u00f3n de las c\u00e9lulas tumorales al diagn\u00f3stico es frecuente y no tiene valor pron\u00f3stico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n molecular de los sarcomas de partes blandas. detecci\u00f3n de la enfermedad m\u00ednima residual<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n molecular de los sarcomas de partes blandas. detecci\u00f3n de la enfermedad m\u00ednima residual <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anna Llort Sales <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Soledad Gallego Melcon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfredo Gallart catala <\/li>\n<li>Luis Madero lopez (vocal)<\/li>\n<li>aurora Navajas gutierrez (vocal)<\/li>\n<li>n\u00faria Toran puentes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anna Llort Sales Los sarcomas de partes blandas son el tercer grupo de neoplaisas m\u00e1s frecuente durante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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