{"id":5425,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/estudio-de-la-supervivencia-de-los-tumores-fibrohistiociticos-de-los-tejidos-blandos-valor-pronostico-del-oncogen-p53\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"estudio-de-la-supervivencia-de-los-tumores-fibrohistiociticos-de-los-tejidos-blandos-valor-pronostico-del-oncogen-p53","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-supervivencia-de-los-tumores-fibrohistiociticos-de-los-tejidos-blandos-valor-pronostico-del-oncogen-p53\/","title":{"rendered":"Estudio de la supervivencia de los tumores fibrohistiociticos de los tejidos blandos: valor pronostico del oncogen p53."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Gude Sampedro <\/strong><\/h2>\n<p>Los tumores fibrohistiociticos de los tejidos blandos son neoplasias de histogenesis incierta y comportamiento biologico dificilmente predecible en base a estudios histopatologicos de rutina. En el presente trabajo de investigacion original se estudian 88 tumores fibrohistiociticos localizados en los tejidos blandos y obtenidos de los archivos del departamento de anatomia patologica del hospital general de galicia y clinico universitario de santiago durante un periodo de veinte a\u00f1os (1974-1993). La serie incluye 7 fibroxantomas atipicos (fxa), 39 dermatofibrosarcomas protuberans (dfsp) y 42 histiocitomas fibrosos malignos (hfm), y el tiempo de seguimiento clinico de los pacientes oscilo de 1 a 144 meses, con un seguimiento medio de 39 meses. Se realizaron determinaciones inmunohistoquimicas de la expresion del oncogen p53 en todos los 88 casos (18% no valorables) clasificando a los tumores en p53 positivos y p53 negativos. La determinacion inmunohistoquimica del oncogen p53 revelo que 25 tumores mostraron positividad nuclear de variable intensidad, incluyendo 2 de 6 fxas (33,3%), 7 de 31 casos de dfsp (22,5%) y 16 de 35 hfms (46%). Hemos encontrado asociacion estadisticamente significativa en la relacion de la expresion de p53 con la aparicion de recidivas (p=0,00001, riesgo relativo estimado=4,3) asi como con el desarrollo de metastasis (p=0,00012, riesgo relativo estimado=3,2). Se observaron tambien valores significativos en la relacion entre la expresion del oncogen p53 y la muerte por tumor tanto en el grupo total de 88 tumores (p=0,00673, riesgo relativo estimado=2,7) como en la serie de 42 casos de hfm (p=0,0497, riesgo relativo estimado=2,2). Por ultimo, las curvas de supervivencia de kaplan y meier mostraron una supervivencia mas alta en pacientes cuyos tumores eran p53 negativos frente a los casos que expresaban el oncogen p53 (test log-rank, p=0,0110). Cuando ajustamos por la edad, el riesgo de fallecimiento se multiplic<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la supervivencia de los tumores fibrohistiociticos de los tejidos blandos: valor pronostico del oncogen p53.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la supervivencia de los tumores fibrohistiociticos de los tejidos blandos: valor pronostico del oncogen p53. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Gude Sampedro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Varela Duran<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Benito Regueiro Garcia <\/li>\n<li>Mar\u00eda no Toro Rojas (vocal)<\/li>\n<li>Juan Cuevas \u00e1lvarez (vocal)<\/li>\n<li>Josefina Fanego Fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Gude Sampedro Los tumores fibrohistiociticos de los tejidos blandos son neoplasias de histogenesis incierta y comportamiento [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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