{"id":54271,"date":"2018-03-09T22:42:00","date_gmt":"2018-03-09T22:42:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-genetico-del-sistema-de-captacion-de-hemo-en-vibrio-anguillarum-caracterizacion-estructural-y-funcional\/"},"modified":"2018-03-09T22:42:00","modified_gmt":"2018-03-09T22:42:00","slug":"analisis-genetico-del-sistema-de-captacion-de-hemo-en-vibrio-anguillarum-caracterizacion-estructural-y-funcional","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/analisis-genetico-del-sistema-de-captacion-de-hemo-en-vibrio-anguillarum-caracterizacion-estructural-y-funcional\/","title":{"rendered":"An\u00e1lisis gen\u00e9tico del sistema de captaci\u00f3n de hemo en vibrio anguillarum: caracterizaci\u00f3n estructural y funcional"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Mouri\u00f1o L\u00f3pez <\/strong><\/h2>\n<p>Vibrio anguillarum es uno de los principales agentes etiol\u00f3gicos de la vibriosis de los peces. Entre los diversos mecanismos de virulencia que posee, destaca su capacidad para obtener el hierro a partir de distintas fuentes presentes en el hospedador, entre ellas los grupos hemo. En esta tesis doctoral se ha llevado a cabo la caracterizaci\u00f3n estructural y funcional de un cluster g\u00e9nico que codifica la captaci\u00f3n y transporte de la mol\u00e9cula de hemo desde el medio extracelular hasta el citoplasma bacteriano, analizando el posible papel que juega este mecanismo de obtenci\u00f3n de hierro en la supervivencia y multiplicaci\u00f3n del microorganismo durante el proceso infectivo. El sistema tang\u00e9nico descrito est\u00e1 compuesto por nueve genes organizados en tres unidades transcripcionales (gen huva y los operones huvxz y tonb1exbbd1-huvbcd() y cuya expresi\u00f3n est\u00e1 regulada por la concentraci\u00f3n de hierro intracelular, a trav\u00e9s del regulador transcripcional fur. Asimismo, la detecci\u00f3n de secuencias del cluster g\u00e9nico descrito en distintas cepas de v.Anguillarum de serotipos o1 al o10, confirma que la capacidad de utilizaci\u00f3n de hemo es una caracter\u00edstica propia de la especie. Sin embargo, se ha puesto de manifiesto una notable variabilidad gen\u00e9tica intraespec\u00edfica en el sistema de utilizaci\u00f3n de hemo, ya que \u00fanicamente los genes tonb1, exbb1 y exbd1 est\u00e1n presentes en todas las cepas estudiadas. La identificaci\u00f3n de dos receptores de membrana externa diferentes, huva y huvs, con una baja similitud en la secuencia aminoac\u00eddica, aunque funcionalmente intercambiables, sugiere tambi\u00e9n diferencias filogen\u00e9ticas dentro de v.Anguillarum, o la presencia de eventos de transfernecia g\u00e9nica horizontal finalmente, la caracterizaci\u00f3n y an\u00e1lisis funcional de dos complejos tonb (tonb1 y tonb2) en v.Anguillarum, han demostrado la participaci\u00f3n de ambos sistemas en distintos mecanismos de obtenci\u00f3n de hierro, siendo funcionalmente intercambiables para la utilizaci\u00f3n de hem<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis gen\u00e9tico del sistema de captaci\u00f3n de hemo en vibrio anguillarum: caracterizaci\u00f3n estructural y funcional<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis gen\u00e9tico del sistema de captaci\u00f3n de hemo en vibrio anguillarum: caracterizaci\u00f3n estructural y funcional <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Mouri\u00f1o L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Lemos Ramos Manuel Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Barja p\u00e9rez Juan  Luis <\/li>\n<li>carmen Amaro gonz\u00e1lez (vocal)<\/li>\n<li> P\u00e9rez nieto Mar\u00eda teresa (vocal)<\/li>\n<li>susana Merino montero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Mouri\u00f1o L\u00f3pez Vibrio anguillarum es uno de los principales agentes etiol\u00f3gicos de la vibriosis de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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