{"id":54284,"date":"2018-03-09T22:42:00","date_gmt":"2018-03-09T22:42:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilidad-de-la-reaccion-en-cadena-de-la-polimerasa-pcr-en-el-diagnostico-de-la-esquistosomosis\/"},"modified":"2018-03-09T22:42:00","modified_gmt":"2018-03-09T22:42:00","slug":"utilidad-de-la-reaccion-en-cadena-de-la-polimerasa-pcr-en-el-diagnostico-de-la-esquistosomosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/parasitologia-humana\/utilidad-de-la-reaccion-en-cadena-de-la-polimerasa-pcr-en-el-diagnostico-de-la-esquistosomosis\/","title":{"rendered":"Utilidad de la reaccion en cadena de la polimerasa (pcr) en el diagnostico de la esquistosomosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sandoval Martinez Nidia Raquel <\/strong><\/h2>\n<p>La esquistosomosis representa un problema creciente en \u00e1reas no end\u00e9micas debido al aumento del n\u00famero de inmigrantes y de turistas que contraen esta enfermedad. La esquistosomosis aguda no es diagnosticada de forma temprana debido a la falta de herramientas diagn\u00f3sticas que sean lo suficientemente sensibles para detectar el par\u00e1sito durante las primeras semanas de infecci\u00f3n. Los m\u00e9todos actualmente disponibles para el diagn\u00f3stico de la esquistosomosis humana presentan problemas de especificidad y sensibilidad. Recientemente, varios autores han desarrollado m\u00e9todos diagn\u00f3sticos m\u00e1s espec\u00edficos y sensibles, principalmente basados en la t\u00e9cnica de reacci\u00f3n en cadena de la polimerasa (pcr). Sin embargo, estas nuevas aproximaciones se han aplicado s\u00f3lo para el diagn\u00f3stico de una de las cinco especies que afectan al hombre (schistosoma mansoni). Adem\u00e1s, la aplicaci\u00f3n de esta pcr espec\u00edfica solo se ha demostrado en muestras de sangre y heces. En este trabajo, presentamos el desarrollo de una pcr altamente sensible, que permite la amplificaci\u00f3n g\u00e9nero- y especie-espec\u00edfica de las cuatro especies de schistosoma que principalmente causan enfermedad en el hombre. Adem\u00e1s, aplicamos con \u00e9xito esta t\u00e9cnica para la detecci\u00f3n de adn parasitario en muestras de orina f\u00e1ciles de obtener y manejar, de pacientes con esquistosomosis. Con estas muestras, encontramos un 94,4% de sensibilidad y un 99,9% de especificidad al aplicar los primers g\u00e9nero(schistosoma ssp.)-Espec\u00edficos, y un 100% de sensibilidad y un 98,9% de especificidad en la pcr especie(s. Mansoni)-espec\u00edfica. igualmente hemos desarrollado una aproximaci\u00f3n diagn\u00f3stica basada en la detecci\u00f3n de adn parasitario por la pcr en orina, comparando la utilidad de esta nueva aproximaci\u00f3n con aquella de las dos herramientas m\u00e1s com\u00fanmente utilizadas en el diagnostico de la esquistosomosis (kato-katz y elisa), as\u00ed como con la pcr en heces. Esta comparaci\u00f3n se hizo en un modelo experimental murino d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilidad de la reaccion en cadena de la polimerasa (pcr) en el diagnostico de la esquistosomosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilidad de la reaccion en cadena de la polimerasa (pcr) en el diagnostico de la esquistosomosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sandoval Martinez Nidia Raquel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Muro \u00e1lvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Mas coma <\/li>\n<li>vicente Ramajo (vocal)<\/li>\n<li>Jos\u00e9 Luis Perez arellano (vocal)<\/li>\n<li>Antonio Benito (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sandoval Martinez Nidia Raquel La esquistosomosis representa un problema creciente en \u00e1reas no end\u00e9micas debido al aumento [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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