{"id":54288,"date":"2018-03-09T22:42:00","date_gmt":"2018-03-09T22:42:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/prevencion-y-tratamiento-del-sa%c2%adndrome-de-hiperestimulacion-ovarica-s-h-o-mediante-el-empleo-de-cabergolina-como-agonista-dopaminergico\/"},"modified":"2018-03-09T22:42:00","modified_gmt":"2018-03-09T22:42:00","slug":"prevencion-y-tratamiento-del-sa%c2%adndrome-de-hiperestimulacion-ovarica-s-h-o-mediante-el-empleo-de-cabergolina-como-agonista-dopaminergico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/prevencion-y-tratamiento-del-sa%c2%adndrome-de-hiperestimulacion-ovarica-s-h-o-mediante-el-empleo-de-cabergolina-como-agonista-dopaminergico\/","title":{"rendered":"Prevenci\u00f3n y tratamiento del s\u00edndrome de hiperestimulaci\u00f3n ov\u00e1rica (s.h.o) mediante el empleo de cabergolina como agonista dopamin\u00e9rgico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel Gonz\u00e1lez Izquierdo <\/strong><\/h2>\n<p>Concepto: respuesta suprafisiol\u00f3gica del ovario desencadenada pr\u00e1cticamente siempre tras la administraci\u00f3n ex\u00f3gena de hcg en la culminaci\u00f3n de un ciclo de hiperestimulaci\u00f3n ov\u00e1rica controlada.  hip\u00f3tesis: como culminaci\u00f3n al proceso de estimulaci\u00f3n ov\u00e1rica, la administraci\u00f3n de hcg induce la sobreexpresi\u00f3n de vegf a nivel ov\u00e1rico. Tras la uni\u00f3n de vegf a vegfr2 se produce la activaci\u00f3n del receptor que desembocar\u00e1 en la permeabilidad vascular incrementada que origina el s\u00edndrome. Puesto que el primer paso de activaci\u00f3n de vegfr2 implica la fosforilaci\u00f3n del receptor, nosotros sostenemos que la administraci\u00f3n de la cabergolina, bloquear\u00e1 la fosforilaci\u00f3n de vegfr2 y con ello la cascada enzim\u00e1tica que desemboca en los incrementos de permeabilidad vascular que caracteriza al s\u00edndrome.  material y m\u00e9todos: el modelo de experimentaci\u00f3n animal utilizado son ratas wistar de 22 d\u00edas de vida (inmaduras, sin ciclos menstruales) de 45 a 65 g. De peso al que se le desarrolla el sho mediante la estimulaci\u00f3n folicular con gonadotropinas extra\u00eddas de orina de yegua gr\u00e1vida con 10 ui diarias durante 4 d\u00edas  y posteriormente 30 ui de hcg, produciendo en el 100 % de los casos el desarrollo del sho que objetivamos mediante el agrandamiento de los ovarios (con m\u00faltiples quistes) y  ascitis (medida seg\u00fan el m\u00e9todo descrito por ujioka y cols, 1997 y g\u00f3mez y cols, 2002). utilizamos la cabergolina, como agonista dopamin\u00e9rgico, porque en los estudios de gen\u00f3mica sobre las diferencias en la expresi\u00f3n g\u00e9nica entre los ovarios de ratas con sho y los controles, el gen de la tiroxin ohasa aparece infraexpresado, siendo esta enzima la clave en la regulaci\u00f3n de la s\u00edntesis de la dopamina. dise\u00f1amos tres protocolos diferentes de administraci\u00f3n de cabergolina, el primero llamado \u00bb prevenci\u00f3n\u00bb dimos la cabergolina oral durante los cuatro d\u00edas de estimulaci\u00f3n folicular,  el d\u00eda de la hcg y 24h despu\u00e9s. en el segundo protoc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Prevenci\u00f3n y tratamiento del s\u00edndrome de hiperestimulaci\u00f3n ov\u00e1rica (s.h.o) mediante el empleo de cabergolina como agonista dopamin\u00e9rgico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Prevenci\u00f3n y tratamiento del s\u00edndrome de hiperestimulaci\u00f3n ov\u00e1rica (s.h.o) mediante el empleo de cabergolina como agonista dopamin\u00e9rgico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel Gonz\u00e1lez Izquierdo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Pellicer Martinez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lorenzo Abad Martinez <\/li>\n<li> Matorras weining Jos\u00e9 roberto (vocal)<\/li>\n<li>Javier Ferrer barriendos (vocal)<\/li>\n<li>Jos\u00e9 Schneider fontan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel Gonz\u00e1lez Izquierdo Concepto: respuesta suprafisiol\u00f3gica del ovario desencadenada pr\u00e1cticamente siempre tras la administraci\u00f3n ex\u00f3gena de hcg [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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