{"id":54296,"date":"2018-03-09T22:42:00","date_gmt":"2018-03-09T22:42:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-respuesta-genica-al-dolor-por-el-represor-transcripcional-dream\/"},"modified":"2018-03-09T22:42:00","modified_gmt":"2018-03-09T22:42:00","slug":"regulacion-de-la-respuesta-genica-al-dolor-por-el-represor-transcripcional-dream","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/regulacion-de-la-respuesta-genica-al-dolor-por-el-represor-transcripcional-dream\/","title":{"rendered":"Regulaci\u00f3n de la respuesta g\u00e9nica al dolor por el represor transcripcional dream"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jorge Barrio Burgos <\/strong><\/h2>\n<p>The dream protein (downstream regulatory element antagonist modulator) protein regulates gene expresion by direct binding to dna in a ca2+-dependent manner. To investigate the function of dream in vivo, we have prepared and characterized several lines of transgenic mice which overespress a calcium insensitive ef-hand mutant dream (efmdream). Both in vitro and vivo, efmdream functions a dominant active mutant (dadream) blocking calcium-mediated de-repression of target genes. Overexpression of dadream in the cns resulted in an increase of the nociceptive response in several pain models. This findig correlates with the the important  reduction in the opioid tone in dadream mice with a significant decrease in the expression of all three opioid receptors as well as dynorphines. Comparative gene profiling analisys of dadream revealed important differences in genetic response compared with wild type mice. The pattern of gene expression in dadream is similar to the chronic pain model  gene expression pattern.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la respuesta g\u00e9nica al dolor por el represor transcripcional dream<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la respuesta g\u00e9nica al dolor por el represor transcripcional dream <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jorge Barrio Burgos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ramon Naranjo Orovio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carmen Mar\u00eda Gonzalez garcia <\/li>\n<li>rosario Moratolla (vocal)<\/li>\n<li>bel\u00e9n Pintado (vocal)<\/li>\n<li>Ana Ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jorge Barrio Burgos The dream protein (downstream regulatory element antagonist modulator) protein regulates gene expresion by direct [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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