{"id":54317,"date":"2018-03-09T22:42:00","date_gmt":"2018-03-09T22:42:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evolucio-dels-mecanismes-de-control-del-metabolsime-del-glicogen\/"},"modified":"2018-03-09T22:42:00","modified_gmt":"2018-03-09T22:42:00","slug":"evolucio-dels-mecanismes-de-control-del-metabolsime-del-glicogen","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/evolucio-dels-mecanismes-de-control-del-metabolsime-del-glicogen\/","title":{"rendered":"Evoluci\u00f3 dels mecanismes de control del metabolsime del glicogen"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Daniel Cifuentes Buira <\/strong><\/h2>\n<p>En la red metab\u00f3lica molecular, miles de sustratos est\u00e1n interconectados mediante reacciones bioqu\u00edmicas. A pesar que este alto grado de conexi\u00f3n podr\u00eda desembocar en el flujo de sustratos en m\u00faltiples direcciones, a la pr\u00e1ctica los flujos metab\u00f3licos se canalizan a trav\u00e9s de v\u00edas metab\u00f3licas espec\u00edficas. Un punto clave para la comprensi\u00f3n dela organizaci\u00f3n celular y la homeostasis del organismo es entender c\u00f3mo se definen estos m\u00f3dulos funcionales y se a\u00edslan unos de otros para asegurar el correcto funcionamiento del organismo.     para responder esta cuesti\u00f3n utilizamos el metabolismo del gluc\u00f3geno como modelo de estudio, en particular la relaci\u00f3n que se establece entre las gluc\u00f3geno sintasas (gs) y las hexoquinasas (hk1 i gk), a trav\u00e9s de la glucosa-6-fosfato (g6p). Con la sobreexpresi\u00f3n de la hk1 y la gk mediante adenovirus recombinantes demostramos que la gk induce  mejor que la hk1 la activaci\u00f3n de la gs hep\u00e1tica mediada por g6p porque la gk sintetiza m\u00e1s eficientemente las elevadas concentraciones de g6p que requiere la activaci\u00f3n de la gs hep\u00e1tica.     mediante el an\u00e1lisis de las fiogenias y del patr\u00f3n de expresi\u00f3n de los isoenzimas implicados en el metabolismo del gluc\u00f3geno, de las hexoquinasas, gluc\u00f3geno sintasas y transportadores de glucosa (glut), indica que la aparici\u00f3n de isoformas espec\u00edficas de tejido en el origen de los vertebrados mediante duplicaci\u00f3n g\u00e9nica, contribuye a la creaci\u00f3n de m\u00f3dulos metab\u00f3licos independientes.     la visi\u00f3n global que nos proporcionan los estudios evolutivos junto con los datos bioqu\u00edmicos previos, confirma que los dos t\u00e1ndems de isoenzimas, glut2\/gk\/gs hep\u00e1tica y glut4\/hk\/gs muscular, co-evolucionan para adaptarse a las necesidades metab\u00f3licas caracter\u00edsticas del tejido en el cual se expresan.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evoluci\u00f3 dels mecanismes de control del metabolsime del glicogen<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evoluci\u00f3 dels mecanismes de control del metabolsime del glicogen <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Daniel Cifuentes Buira <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Guinovart Cirera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Pouplana lLuis ribas de (secretario) <\/li>\n<li>cedric Notredame (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daniel Cifuentes Buira En la red metab\u00f3lica molecular, miles de sustratos est\u00e1n interconectados mediante reacciones bioqu\u00edmicas. A [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,849,36483],"tags":[119942,119940,13699,119941],"class_list":["post-54317","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-biologia-celular","category-biologia-molecular","tag-cedric-notredame","tag-daniel-cifuentes-buira","tag-joan-guinovart-cirera","tag-pouplana-lluis-ribas-de-secretario"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54317","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=54317"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54317\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=54317"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=54317"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=54317"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}