{"id":54503,"date":"2006-11-09T00:00:00","date_gmt":"2006-11-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-inmunofenotipica-del-cancer-de-cuello-uterino-asociado-a-infeccion-por-virus-papiloma-humano-hpv\/"},"modified":"2006-11-09T00:00:00","modified_gmt":"2006-11-09T00:00:00","slug":"caracterizacion-inmunofenotipica-del-cancer-de-cuello-uterino-asociado-a-infeccion-por-virus-papiloma-humano-hpv","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-inmunofenotipica-del-cancer-de-cuello-uterino-asociado-a-infeccion-por-virus-papiloma-humano-hpv\/","title":{"rendered":"Caracterizacion inmunofenotipica del cancer de cuello uterino asociado a infeccion por virus papiloma humano (hpv)"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Toro De Mendez Morelva <\/strong><\/h2>\n<p>Se llev\u00f3 a cabo un estudio inmunohistoqu\u00edmico incluyendo un panel de 18 biomarcadores y un estudio molecular en 81 biopsias de c\u00e1ncer de cuello uterino (59 carcinomas epidermoides y 19 adenocarcinomas cervicales) diagnosticados en el servicio de anatom\u00eda patol\u00f3gica del hospital cl\u00ednico universitario de Valencia, con la finalidad de realizar la caracterizaci\u00f3n inmunohistoqu\u00edmica de esta neoplasia invasora y determinar la presencia de adn-hpv asociado. el estudio inmunohistoqu\u00edmico se realiz\u00f3, en tumores cervicales y tejido cervical benigno como control, mediante la t\u00e9cnica de avidina-biotina, interpretado siguiendo una escala semicuantitativa. Se determin\u00f3 la presencia y genotipificaci\u00f3n de adn-hpv, en las muestras neopl\u00e1sicas, utilizando el m\u00e9todo pcr-spf10\/lipa.  el tipo histol\u00f3gico m\u00e1s frecuente fue el carcinoma epidermoide moderadamente diferenciado (43.5%) y el adenocarcinoma endocervical (42.1%). La edad promedio de las pacientes fue 50.67 m\u00e1s o menos 13.62 a\u00f1os. Los hallazgos inmunohistoqu\u00edmicos fueron los siguientes: los carcinomas cervicales mostraron un \u00edndice proliferativo (ki-67\/mib-1) entre moderado y alto; presentaron inmunoreactividad positiva para las prote\u00ednas celulares reguladoras ciclina d1, prb, p16, p21, p27 y ciclina e igual a 32.1%, 30%, 79.5%, 52.5%, 53.2% y 7.7% respectivamente. Respecto a las prote\u00ednas apopt\u00f3ticas, la reactividad ante el anticuerpo contra p53 fue de 3.9%, mdm-2 (100%), bax (67.5%) y bci-2 (3.7%). Las mol\u00e9culas de adhesi\u00f3n celular cadherina-e, cd44s y cd44v3 estaban sobrexpresadas con localizaci\u00f3n preferentemente citoplasm\u00e1tica en el 76.6%, 90.9% y 97.5%. La inmunorespuesta para la ubicuitina fue de 98.7%, citoqueratinas (ae1\/ae3) 97,5%, cea 89.7% y telomerasa 52.6%. Se encontraron diferencias estad\u00edsticamente significativas en la inmunoreactividad de los tumores en comparaci\u00f3n con los controles a excepci\u00f3n de la reactividad de p53, bcl-2 y cea; tambien en cuanto a la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion inmunofenotipica del cancer de cuello uterino asociado a infeccion por virus papiloma humano (hpv)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion inmunofenotipica del cancer de cuello uterino asociado a infeccion por virus papiloma humano (hpv) <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Toro De Mendez Morelva <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/09\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Llombart Bosch<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Garcia de lomas barrionuevo <\/li>\n<li>Jos\u00e9 Antonio L\u00f3pez guerrero (vocal)<\/li>\n<li>bel\u00e9n Lloveras  rubio (vocal)<\/li>\n<li>ausente No actuo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Toro De Mendez Morelva Se llev\u00f3 a cabo un estudio inmunohistoqu\u00edmico incluyendo un panel de 18 biomarcadores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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