{"id":54532,"date":"2018-03-09T22:42:16","date_gmt":"2018-03-09T22:42:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-las-isoformas-alfa-beta-gamma-y-delta-de-la-map-quinasa-p38-en-la-infeccion-por-vih-1-de-celulas-t-cd4\/"},"modified":"2018-03-09T22:42:16","modified_gmt":"2018-03-09T22:42:16","slug":"implicacion-de-las-isoformas-alfa-beta-gamma-y-delta-de-la-map-quinasa-p38-en-la-infeccion-por-vih-1-de-celulas-t-cd4","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicacion-de-las-isoformas-alfa-beta-gamma-y-delta-de-la-map-quinasa-p38-en-la-infeccion-por-vih-1-de-celulas-t-cd4\/","title":{"rendered":"Implicaci\u00f3n de las isoformas alfa, beta, gamma y delta de la map quinasa p38 en la infecci\u00f3n por vih-1 de c\u00e9lulas t cd4+."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Dolores Guti\u00e9rrez Sanmart\u00edn <\/strong><\/h2>\n<p>El objetivo de esta tesis est\u00e1 dirigido al estudio de las bases moleculares mediante las cuales el vih-1 es capaz de destruir c\u00e9lulas t del organismo por un mecanismo de apoptosis. En nuestro caso en concreto, el estudio se centr\u00f3 en las isoformas alfa, beta, gamma y delta de la map quinasa p38. El uso de dichas mol\u00e9culas en su versi\u00f3n dominante negativa result\u00f3 en una prolongaci\u00f3n de la supervivencia de linfocitos t cd4+ por parte de las isoformas alfa, gamma y delta dominante negativas, pero no por parte de la isoforma beta dominante negativa. Esto fue debido a la implicaci\u00f3n de las isoformas alfa, gamma y delta de p38 en la replicaci\u00f3n del vih-1, y a la implicaci\u00f3n de las isoformas alfa y gamma de p38 en la apoptosis celular inducida por este virus. Estos resultados permiten avanzar en el conocimiento del mecanismo de patog\u00e9nesis del vih-1, y ofrecen la posibilidad de un tratamiento complementario a los f\u00e1rmacos antirretrovirales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n de las isoformas alfa, beta, gamma y delta de la map quinasa p38 en la infecci\u00f3n por vih-1 de c\u00e9lulas t cd4+.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n de las isoformas alfa, beta, gamma y delta de la map quinasa p38 en la infecci\u00f3n por vih-1 de c\u00e9lulas t cd4+. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Dolores Guti\u00e9rrez Sanmart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/09\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Benito Regueiro Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 angel Garc\u00eda rodr\u00edguez <\/li>\n<li>Jos\u00e9 Alcami pertejo (vocal)<\/li>\n<li>Antonio Antela l\u00f3pez (vocal)<\/li>\n<li>Rafael Seoane prado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Dolores Guti\u00e9rrez Sanmart\u00edn El objetivo de esta tesis est\u00e1 dirigido al estudio de las bases moleculares mediante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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