{"id":54586,"date":"2018-03-09T22:42:19","date_gmt":"2018-03-09T22:42:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-inmunoanalisis-para-la-determinacion-de-la-coriogonadotropina-humana\/"},"modified":"2018-03-09T22:42:19","modified_gmt":"2018-03-09T22:42:19","slug":"desarrollo-de-inmunoanalisis-para-la-determinacion-de-la-coriogonadotropina-humana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-clinica\/desarrollo-de-inmunoanalisis-para-la-determinacion-de-la-coriogonadotropina-humana\/","title":{"rendered":"Desarrollo de inmunoanalisis para la determinacion de la coriogonadotropina humana"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alejandro Gella Concustell <\/strong><\/h2>\n<p>La tesis est\u00e1 orientada en \u00faltima instancia al desarrollo de inmunoan\u00e1lisis para la determinaci\u00f3n de la coriogonadotropina (hcg) en muestras de suero o de orina humanas. los primeros m\u00e9todos utilizados para la determinaci\u00f3n de la hcg eran \u00abbioensayos\u00bb y luego \u00abradioinmunoensayos\u00bb. Ambos perdieron vigencia por diversas causas: laboriosos, poco sensibles y poco espec\u00edficos (bioensayos), necesidad de instalaciones reguladas, etc. Cuando la hcg purificada fue asequible, pudieron prepararse anticuerpos espec\u00edficos y se desarrollaron diversos tipos de inmunoan\u00e1lisis con mejores prestaciones que los \u00abbioensayos\u00bb y mayor facilidad de uso que el \u00abradioinmunoan\u00e1lisis\u00bb. En los casos en que la determinaci\u00f3n se realiza como prueba r\u00e1pida de embarazo, son especialmente \u00fatiles determinadas variantes de inmunoan\u00e1isis denominadas \u00abpruebas r\u00e1pidas\u00bb, que no precisan de instrumenteal y pueden ser realizadas por personal no especilaizado. en el presente trabajo se han desarrollado y validado dos sistemas de ensayo para la determinaci\u00f3n de la hcg. Por un lado un enzimoinmunoan\u00e1lisis en microplacas para realizar determinaciones cuantitativas de en muestras de suero sanguineo y por otro lado una inmunocromatografia en nitrocelulosa para realizar determinaciones cualitativas en muestras de orina y orientada como prueba r\u00e1pida de embarazo. adem\u00e1s se han desarrollado diversas tecnolog\u00edas aplicables a la obtenci\u00f3n de materias primas de origen biol\u00f3gico que intervienen en los inmunoan\u00e1lisis como la obtenci\u00f3n y purificaci\u00f3n de la hcg, la obtenci\u00f3n y purificaci\u00f3n de anticuerpos monoclonales contra la hcg, la preparaci\u00f3n de nanopart\u00edculas de oro coloidal a gran escala y la conjugaci\u00f3n de anticuerpos contra la hcg con peroxidasa y con oro coloidal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de inmunoanalisis para la determinacion de la coriogonadotropina humana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de inmunoanalisis para la determinacion de la coriogonadotropina humana <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alejandro Gella Concustell <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/09\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Gella Tomas Francisco Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: francesc Gonz\u00e1lez sastre <\/li>\n<li>xavier Fuentes arderiu (vocal)<\/li>\n<li>Antonio Elduque terron (vocal)<\/li>\n<li>gloria Gonzalez anadon (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alejandro Gella Concustell La tesis est\u00e1 orientada en \u00faltima instancia al desarrollo de inmunoan\u00e1lisis para la determinaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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