{"id":54595,"date":"2018-03-09T22:42:19","date_gmt":"2018-03-09T22:42:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/a-genetic-screen-for-new-polycomb-group-genes-in-drosophila-melanogaster\/"},"modified":"2018-03-09T22:42:19","modified_gmt":"2018-03-09T22:42:19","slug":"a-genetic-screen-for-new-polycomb-group-genes-in-drosophila-melanogaster","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica-animal\/a-genetic-screen-for-new-polycomb-group-genes-in-drosophila-melanogaster\/","title":{"rendered":"A genetic screen for new polycomb group genes in drosophila melanogaster"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gayt\u00e1n De Ayala Alonso Andr\u00e9s <\/strong><\/h2>\n<p>Los genes del grupo polycomb (pcg) codifican represores transcripcionales capaces de mantener estados de represi\u00f3n g\u00e9nica de generaci\u00f3n en generaci\u00f3n celular. La represi\u00f3n mediada por el pcg se conoce especialmente por su mantenimiento del patr\u00f3n de expresi\u00f3n de los genes home\u00f3ticos hox en mam\u00edferos e insectos: mutantes en genes del pcg muestran expresi\u00f3n de genes hox fuera de su dominio apropiado de expresi\u00f3n, dando lugar a transformaciones home\u00f3ticas. en esta tesis se describe la metodolog\u00eda y los resultados de un \u00abscreen\u00bb gen\u00e9tico en busca de nuevos genes del pcg en la mosca de la fruta. Se mutagenizaron machos de d. Melanogaster mediante etil metanosulfonato, y se utiliz\u00f3 el sistema flp-frt en su descendencia para identificar mutantes en genes del pcg mediante un fenotipo espec\u00edfico. Se consideraron mutantes del pcg aqu\u00e9llos que mostraron dicho fenotipo y, adem\u00e1s, mostraban expresi\u00f3n del gen hox ubx en el disco imaginal del ala. uno de los nuevos loci identificados codifica una enzima deubiquitinasa cuya actividad catal\u00edtica es necesaria para su funci\u00f1on de represi\u00f3n de genes hox. Tambi\u00e9n se obtuvieron mutantes para med12 y med13, dos componentes del complejo mediador, un complejo multiproteico regulador de la transcripci\u00f3n, lo que sugiere una implicaci\u00f3n del complejo mediador en la represi\u00f3n mediada por el pcg.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>A genetic screen for new polycomb group genes in drosophila melanogaster<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 A genetic screen for new polycomb group genes in drosophila melanogaster <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gayt\u00e1n De Ayala Alonso Andr\u00e9s <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/09\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>J\u00c1\u00bcrg M\u00c1\u00bcller<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Bella sombria <\/li>\n<li>Miguel angel Vidal caballero (vocal)<\/li>\n<li>\u00e1ngel Rodr\u00edguez nebreda (vocal)<\/li>\n<li>montserrat Corominas i guiu (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gayt\u00e1n De Ayala Alonso Andr\u00e9s Los genes del grupo polycomb (pcg) codifican represores transcripcionales capaces de mantener [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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