{"id":54634,"date":"2018-03-09T22:42:23","date_gmt":"2018-03-09T22:42:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/barreras-naturales-para-las-horquillas-de-replicacion-del-dna-en-schizosaccharomyces-pombe\/"},"modified":"2018-03-09T22:42:23","modified_gmt":"2018-03-09T22:42:23","slug":"barreras-naturales-para-las-horquillas-de-replicacion-del-dna-en-schizosaccharomyces-pombe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/barreras-naturales-para-las-horquillas-de-replicacion-del-dna-en-schizosaccharomyces-pombe\/","title":{"rendered":"Barreras naturales para las horquillas de replicaci\u00f3n del dna en schizosaccharomyces pombe"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Leonor Rodr\u00edguez S\u00e1nchez <\/strong><\/h2>\n<p>Los objetivos de esta tesis han sido el estudio de la funci\u00f3n de las prote\u00ednas reb1p y rff1p, par\u00e1logos entre s\u00ed, en la parada de las horquillas de replicaci\u00f3n s.Pombe. As\u00ed mismo, se ha analizado la formaci\u00f3n de complejos de estas prote\u00ednas en la secuencia de dna de las barreras rfb2 y 3 de las genes de rrna. Finalmente, se ha estudiado tambi\u00e9n el papel que juega reb1p en la diferenciaci\u00f3n sexual de s.Pombe.     en esta tesis, se muestra c\u00f3mo a pesar de la alta homolog\u00eda de secuencia existente entre reb1 y rff1p, estas dos prote\u00ednas no son intercambiables en su actividad como factores requeridos para el bloqueo de las horquillas de replicaci\u00f3n. Sin embargo, en las barreras refb2 y 3 se forman una serie de complejos dna-prote\u00ednas dependientes de reb1p y de rff1p.     por otra parte, se han analizado tambi\u00e9n algunas caracter\u00edsticas fenot\u00edpicas de la estirpe reb1.     finalmente, se ha demostrado la implicaci\u00f3n de reb1p en el proceso de parada de las c\u00e9lulas en la fas g1 del ciclo celular, necesaria para que se produzca la conjugaci\u00f3n. Esta implicaci\u00f3n parece mediada por la capacidad de reb1p de promover la sobre expresi\u00f3n del gen ste9+, necesario para la parada en fase g1. Se demuestra que en la zona promotora del gen ste9+, se forma una serie de complejos prote\u00edna-dna in vitro id\u00e9nticos a los observados sobrelas barreras rfb2 y 3 del rdna, que desaparecen en un medio inductor de conjugaci\u00f3n (ayuno de nitr\u00f3geno), manteni\u00e9ndose s\u00f3lo el complejo correspondiente a reb1p. Estos resultados, indican que los complejos podr\u00edan estar unidos a esta secuencia promotora inhibiendo la sobre expresi\u00f3n de ste9+ y que en condiciones de cultivo inductora de conjugaci\u00f3n, esos complejos se liberan manteni\u00e9ndose unida s\u00f3lo la prote\u00edna rebe1p, que promueve la sobre expresi\u00f3n de ste9+, favoreciendo la conjugaci\u00f3n y la diferencia sexual.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Barreras naturales para las horquillas de replicaci\u00f3n del dna en schizosaccharomyces pombe<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Barreras naturales para las horquillas de replicaci\u00f3n del dna en schizosaccharomyces pombe <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Leonor Rodr\u00edguez S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/09\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pablo Hern\u00e1ndez Valenzuela<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Tormo garrido <\/li>\n<li>sergio Moreno p\u00e9rez (vocal)<\/li>\n<li> S\u00e1nchez p\u00e9rez Mar\u00eda isabel (vocal)<\/li>\n<li>crisanto Gutierrez armenta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Leonor Rodr\u00edguez S\u00e1nchez Los objetivos de esta tesis han sido el estudio de la funci\u00f3n de las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[6307,45238,120702,57552,120703,9241],"class_list":["post-54634","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-antonio-tormo-garrido","tag-crisanto-gutierrez-armenta","tag-leonor-rodriguez-sanchez","tag-pablo-hernandez-valenzuela","tag-sanchez-perez-maria-isabel","tag-sergio-moreno-perez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=54634"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54634\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=54634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=54634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=54634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}