{"id":54821,"date":"2018-03-09T22:42:34","date_gmt":"2018-03-09T22:42:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bases-moleculares-de-la-deplecion-de-glutation-y-de-la-necrosis-celular-en-la-pancreatitis-aguda-papel-de-las-protea%c2%adn-quinasas-activadas-por-mitogenos\/"},"modified":"2018-03-09T22:42:34","modified_gmt":"2018-03-09T22:42:34","slug":"bases-moleculares-de-la-deplecion-de-glutation-y-de-la-necrosis-celular-en-la-pancreatitis-aguda-papel-de-las-protea%c2%adn-quinasas-activadas-por-mitogenos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/bases-moleculares-de-la-deplecion-de-glutation-y-de-la-necrosis-celular-en-la-pancreatitis-aguda-papel-de-las-protea%c2%adn-quinasas-activadas-por-mitogenos\/","title":{"rendered":"Bases moleculares de la depleci\u00f3n de glutati\u00f3n y de la necrosis celular en la pancreatitis aguda. papel de las prote\u00edn quinasas activadas por mit\u00f3genos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Pereda Cervera <\/strong><\/h2>\n<p>Introducci\u00f3n:   la pancreatitis aguda es una enfermedad de gran importancia debido a su frecuencia relativamente alta y a una incidencia creciente en nuestros d\u00edas asociada a litiasis biliar y alcoholismo. Adem\u00e1s, la pancreatitis grave presenta un porcentaje elevado de mortalidad. Los mecanismos moleculares que provocan una pancreatitis as\u00ed como los que producen complicaciones locales y sist\u00e9micas que desencadenan una pancreatitis grave no est\u00e1n del todo esclarecidos. El glutati\u00f3n, que es un antioxidante intracelular de gran importancia, se depleciona en el p\u00e1ncreas durante la pancreatitis aguda. Esta depleci\u00f3n influye en la mortalidad celular y en el pron\u00f3stico de la pancreatitis inducida experimentalmente. Adem\u00e1s, la reposici\u00f3n mediante glutati\u00f3n \u00e9ster previene gran parte de los efectos perjudiciales de la enfermedad. objetivos:   nuestro objetivo ha sido determinar los mecanismos responsables de la depleci\u00f3n de glutati\u00f3n en el p\u00e1ncreas en la pancreatitis aguda experimental.   Para ello, hemos estudiado el papel de la  -glutamil ciste\u00edna sintetasa (gcs), enzima limitante de la s\u00edntesis de glutati\u00f3n a partir de ciste\u00edna, la relaci\u00f3n entre la depleci\u00f3n de glutati\u00f3n y el tnf- , as\u00ed como el papel de las proteasas y las prote\u00edn quinasas activadas por mit\u00f3genos (map quinasas).   Adem\u00e1s hemos estudiado la relaci\u00f3n entre la depleci\u00f3n de glutati\u00f3n y la mortalidad celular en c\u00e9lulas ar42j, que es una l\u00ednea celular proveniente de p\u00e1ncreas exocrino de rata. material y m\u00e9todos:    para llevar a cabo estos objetivos, hemos utilizado un modelo in vivo de pancreatitis aguda experimental necr\u00f3tico utilizando una perfusi\u00f3n retr\u00f3grada de taurocolato al 3,5% en el conducto biliopancre\u00e1tico, y un modelo edematoso de pancreatitis aguda experimental inducido con cerule\u00edna en ratas. Asimismo, hemos empleado un modelo en ratones utilizando cerule\u00edna.   En cuanto a los modelos in vitro empleados para el estudio del mecanismo de depleci\u00f3n de glut<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bases moleculares de la depleci\u00f3n de glutati\u00f3n y de la necrosis celular en la pancreatitis aguda. papel de las prote\u00edn quinasas activadas por mit\u00f3genos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bases moleculares de la depleci\u00f3n de glutati\u00f3n y de la necrosis celular en la pancreatitis aguda. papel de las prote\u00edn quinasas activadas por mit\u00f3genos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Pereda Cervera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/09\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Sastre Belloch<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Vi\u00f1a ribes <\/li>\n<li>Manuel Antonio Manso mart\u00edn (vocal)<\/li>\n<li>Jes\u00fas De la osada Garc\u00eda (vocal)<\/li>\n<li>daniel Closa autet (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Pereda Cervera Introducci\u00f3n: la pancreatitis aguda es una enfermedad de gran importancia debido a su frecuencia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[115,848,1323],"tags":[41089,121098,66718,7414,34448,62754],"class_list":["post-54821","post","type-post","status-publish","format-standard","hentry","category-bioquimica-molecular","category-citologia","category-patologia-experimental","tag-daniel-closa-autet","tag-javier-pereda-cervera","tag-jesus-de-la-osada-garcia","tag-jose-vina-ribes","tag-juan-sastre-belloch","tag-manuel-antonio-manso-martin"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54821","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=54821"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54821\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=54821"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=54821"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=54821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}