{"id":54834,"date":"2018-03-09T22:42:34","date_gmt":"2018-03-09T22:42:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-fisiopatologico-de-la-accion-de-anticuerpos-igm-anti-gm2-de-un-paciente-sobre-la-union-neuromuscular\/"},"modified":"2018-03-09T22:42:34","modified_gmt":"2018-03-09T22:42:34","slug":"estudio-fisiopatologico-de-la-accion-de-anticuerpos-igm-anti-gm2-de-un-paciente-sobre-la-union-neuromuscular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-fisiopatologico-de-la-accion-de-anticuerpos-igm-anti-gm2-de-un-paciente-sobre-la-union-neuromuscular\/","title":{"rendered":"Estudio fisiopatol\u00f3gico de la accion de anticuerpos igm anti-gm2 de un paciente sobre la uni\u00f3n neuromuscular"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sabat\u00e9 Mart\u00ednez M. Del Mar <\/strong><\/h2>\n<p>Objetivos: determinar la acci\u00f3n de unos anticuerpos anti-gangli\u00f3sidos de un paciente con polineuropat\u00eda cr\u00f3nica motora desmielinizante asociada a un componente monoclonal igm, sobre conducci\u00f3n nerviosa y sobre la neurotransmisi\u00f3n de un mam\u00edfero adulto tanto en un estudio agudo como cr\u00f3nico y, comprobar que los gangli\u00f3sidos est\u00e1n relacionados con la entrada de calcio al terminal nervioso.  metodolog\u00edas empleadas: determinaci\u00f3n de la especificidad del serum del paciente con t\u00e9cnicas de elisa y de immunohptlc utilizando gangli\u00f3sidos comerciales y gangli\u00f3sidos purificados de cerebro bovino, de cerebro humano y de cultivo de c\u00e9lulas yac-1. Purificaci\u00f3n de anticuerpos de la clase igm mediante cromatograf\u00eda de afinidad con anticuerpos de cabra contra igm humana. T\u00e9cnicas de inmunohistoqu\u00edmica para comprobar la fijaci\u00f3n del anticuerpo a la regi\u00f3n presin\u00e1ptica de la uni\u00f3n neuromuscular. Inoculaci\u00f3n local repetitiva de los anticuerpos anti-gangli\u00f3sido en el m\u00fasculo lal de ratones, cada 24 h durante 15 d\u00edas. Utilizaci\u00f3n de prendisolona para reducir la respuesta inflamatoria local. Los controles se realizaron con el mismo protocolo pero inyectando las igm desnaturalizadas por  calor (90 \u00c2\u00bac, 20 min) y otras soluciones fisiol\u00f3gicas sobre el m\u00fasculo. Estudios electrofisiol\u00f3gicos convencionales de neurograf\u00eda motora para determinar potenciales motores compuestos. Estudios electrofisiol\u00f3gicos intracelulares para comprobar el efecto del serum (y su componente monoclonal) del paciente tanto en incubaciones agudas como en los m\u00fasculos tratados cr\u00f3nicamente con las igm anti-gm2.  resultados y conclusiones: se ha llevado a cabo un estudio sobre el papel del serum de un paciente con una neuropat\u00eda cr\u00f3nica desmielinizante motora pura y un componente monoclonal igm que muestra afinidad por gm2 en la uni\u00f3 neuromuscular. Los estudios electrofisiol\u00f3gicos agudos in vitro han mostrado que las igm del paciente inducen una redu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio fisiopatol\u00f3gico de la accion de anticuerpos igm anti-gm2 de un paciente sobre la uni\u00f3n neuromuscular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio fisiopatol\u00f3gico de la accion de anticuerpos igm anti-gm2 de un paciente sobre la uni\u00f3n neuromuscular <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sabat\u00e9 Mart\u00ednez M. Del Mar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Rovira i virgili<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/09\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manel Santaf\u00e9 Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel angel Merchan cifuentes <\/li>\n<li>isabel Illa sendra (vocal)<\/li>\n<li>xavier Navarro acebes (vocal)<\/li>\n<li>marcela Rosato-siri (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sabat\u00e9 Mart\u00ednez M. Del Mar Objetivos: determinar la acci\u00f3n de unos anticuerpos anti-gangli\u00f3sidos de un paciente con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,817,450,3919,965,156,18759],"tags":[29365,121125,121126,9729,121124,13724],"class_list":["post-54834","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-fisiologia-humana","category-inmunopatologia","category-neurofisiologia-humana","category-neuropatologia","category-patologia","category-rovira-i-virgili","tag-isabel-illa-sendra","tag-manel-santafe-Martinez","tag-marcela-rosato-siri","tag-miguel-angel-merchan-cifuentes","tag-sabate-Martinez-m-del-mar","tag-xavier-navarro-acebes"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=54834"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54834\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=54834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=54834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=54834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}