{"id":54858,"date":"2006-02-10T00:00:00","date_gmt":"2006-02-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/marcadores-biologicos-tras-la-hemorragia-intracerebral-y-su-relacion-con-la-evolucion-clinico-radiologica\/"},"modified":"2006-02-10T00:00:00","modified_gmt":"2006-02-10T00:00:00","slug":"marcadores-biologicos-tras-la-hemorragia-intracerebral-y-su-relacion-con-la-evolucion-clinico-radiologica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/marcadores-biologicos-tras-la-hemorragia-intracerebral-y-su-relacion-con-la-evolucion-clinico-radiologica\/","title":{"rendered":"Marcadores biol\u00f3gicos tras la hemorragia intracerebral y su relacion con la evolucion clinico-radiologica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Pilar Delgado Martinez <\/strong><\/h2>\n<p>Tras la hemorragia intracerebral (hic) se desencadenan una serie de procesos que contribuyen al da\u00f1o cerebral secundario que \u00e9sta ocasiona. En dichos procesos participan una serie de mol\u00e9culas susceptibles de ser utilizadas como marcadores de la evoluci\u00f3n cl\u00ednica y radiol\u00f3gica de los pacientes que presentan una hic. los objetivos de la tesis son revisar la literatura referente a dichos procesos y determinar en una amplia muestra de pacientes con hic, los niveles en plasma de d-d\u00edmero, s100b, diversas metaloproteasas y sus inhibidores end\u00f3genos (mmp-2, mmp-3, mmp-9, timp-1 y timp-2) y mol\u00e9culas implicadas en apoptosis (caspasa-3 y fas soluble) y su relaci\u00f3n con la evoluci\u00f3n posterior de los pacientes. entre todos los procesos descritos toman un papel predominante los sistemas de coagulaci\u00f3n-fibrin\u00f3lisis y los fen\u00f3menos de neuroinflamaci\u00f3n. En fases m\u00e1s tard\u00edas, el da\u00f1o cerebral se agrava por la participaci\u00f3n de enzimas proteol\u00edticas y  sustancias derivadas de la lisis de los eritrocitos, entre otros. en nuestros pacientes, todos los marcadores biol\u00f3gicos a estudio se encontraron de forma basal elevados en plasma (a excepci\u00f3n de fas soluble y timp-2) y presentaron un perfil temporal (24 horas, 48 horas, 7\u00c2\u00ba d\u00eda y tercer mes) definido para cada una de ellos.  los niveles basales de d-d\u00edmero predijeron de forma independiente el deterioro neurol\u00f3gico (junto a la presi\u00f3n arterial sist\u00f3lica) y la mortalidad (junto al volumen de la hic). La prote\u00edna s100b se relacion\u00f3 con el volumen inicial de la hic. La mmp-9 y su inhibidor timp-1 se asociaron al edema perihematoma basal y la mmp-3 se asoci\u00f3 al volumen residual al tercer mes y a la mortalidad. entre los marcadores de apoptosis, el fas soluble sufri\u00f3 un descenso significativo, y se asoci\u00f3 al crecimiento posterior del edema. Adem\u00e1s la activaci\u00f3n del sistema fas\/ fas ligando se comprob\u00f3 en las \u00e1reas perihematoma en tejido cerebral.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Marcadores biol\u00f3gicos tras la hemorragia intracerebral y su relacion con la evolucion clinico-radiologica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Marcadores biol\u00f3gicos tras la hemorragia intracerebral y su relacion con la evolucion clinico-radiologica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Pilar Delgado Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 \u00e1lvarez Sab\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>Jos\u00e9 Castillo perez (vocal)<\/li>\n<li> Feliu albi\u00f1ana Juan  emili (vocal)<\/li>\n<li>antoni lLuis Andreu periz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Pilar Delgado Martinez Tras la hemorragia intracerebral (hic) se desencadenan una serie de procesos que contribuyen 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