{"id":54883,"date":"2006-04-10T00:00:00","date_gmt":"2006-04-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/control-transcripcional-i-al-losta%c2%a8ric-del-gen-carnitina-palmitoa%c2%afltransferasa-1b-cpt1b\/"},"modified":"2006-04-10T00:00:00","modified_gmt":"2006-04-10T00:00:00","slug":"control-transcripcional-i-al-losta%c2%a8ric-del-gen-carnitina-palmitoa%c2%afltransferasa-1b-cpt1b","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/control-transcripcional-i-al-losta%c2%a8ric-del-gen-carnitina-palmitoa%c2%afltransferasa-1b-cpt1b\/","title":{"rendered":"Control transcripcional i al-lost\u00e9ric del gen carnitina palmito\u00c1\u00afltransferasa 1b (cpt1b)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joana Relat Pardo <\/strong><\/h2>\n<p>El aumento de triglic\u00e9ridos y acil-coas puede darse en casos de obesidad o hipersecreci\u00f3n de insulina y su acumulaci\u00f3n en tejidos perif\u00e9ricos como m\u00fasculo o p\u00e1ncreas puede afectar a la captaci\u00f3n de glucosa y a la funcionalidad de las c\u00e9lulas beta, respectivamente. El control de los niveles de \u00e1cidos grasos en etapas precoces de la obesidad y la diabetes tipo2 permitir\u00edan, seg\u00fan esto, reducir la hiperinsulinemia y la resistencia a insulina asociadas y evitar la lipotoxicidad provocada por la acumulaci\u00f3n de grasas son metabolizados es la beta-oxidaci\u00f3n mitocondrial. Se trata de un proceso finamente regulado que presenta su punto cr\u00edtico en la entrada de los \u00e1cidos grasos a la matriz mitocondrial. Debido a su hidrofobicidad, los \u00e1cidos grasos de cadena larga son incapaces de atravesar la membrana mitocondrial y requieren de un sistema lanzadera, el sistema carnitina palmitoiitransferasa. Este sistema est\u00e1 formado por tres enzimas que catalizan la translocaci\u00f3n de los \u00e1cidos grasos de cadena larga a trav\u00e9s de un mecanismos dependiente de carnitina. Se trata de un sistema regulado sobre todo a trav\u00e9s de la enzima carnitina palmitoiitransferasa1 (cpt1) que cataliza la formaci\u00f3n de tio\u00e9steres de los acils-coa de los \u00e1cidos grasos de cadena larga con carnitina, generando acilcarnitinas en la membrana mitocondrial externa. La cpt1 es una prote\u00edna controlada nivel transcripcional y a nivel alost\u00e9rico a trav\u00e9s de su inhibidor fisiol\u00f3gico, malonil-coa.     para estudiar los mecanismos de regulaci\u00f3n transcripcional de la cpt1b se utilizaron 380 bp de la regi\u00f3n promotora de la cpt1b humana donde ya hab\u00edan sido caracterizados un elemento de respuesta a receptores activados por proliferadores de peroxisomas (ppar), un elemento de respuesta a factores miog\u00e9nicos de la familia myod. Los resultados obtenidos de experimentos de transfecci\u00f3n transitoria describen un mecanismo sin\u00e9rgico y cooperativo entre pparalfa y mef-2c en la expresi\u00f3n de la cpt1d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Control transcripcional i al-lost\u00e9ric del gen carnitina palmito\u00c1\u00afltransferasa 1b (cpt1b)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Control transcripcional i al-lost\u00e9ric del gen carnitina palmito\u00c1\u00afltransferasa 1b (cpt1b) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joana Relat Pardo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Diego Haro Bautista<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  isabel V\u00e1zquez baanante <\/li>\n<li> Puig miquel Mar\u00eda  teresa (vocal)<\/li>\n<li>Marta Giralt oms (vocal)<\/li>\n<li> Ortiz salcedo Jos\u00e9 Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joana Relat Pardo El aumento de triglic\u00e9ridos y acil-coas puede darse en casos de obesidad o hipersecreci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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