{"id":54884,"date":"2006-04-10T00:00:00","date_gmt":"2006-04-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-endoglina-y-alk-1-en-la-va%c2%ada-de-senalizacion-de-tgf-beta\/"},"modified":"2006-04-10T00:00:00","modified_gmt":"2006-04-10T00:00:00","slug":"papel-de-endoglina-y-alk-1-en-la-va%c2%ada-de-senalizacion-de-tgf-beta","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-endoglina-y-alk-1-en-la-va%c2%ada-de-senalizacion-de-tgf-beta\/","title":{"rendered":"Papel de endoglina y alk-1 en la v\u00edade se\u00f1alizaci\u00f3n de tgf-beta"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier Blanco L\u00f3pez <\/strong><\/h2>\n<p>El endotelio vascular es una monocapa de c\u00e9lulas que tapiza el interior de los vasos sangu\u00edneos y que se encuentra en contacto directo con el torrente circulatorio. El proceso de formaci\u00f3n de nuevos vasos sangu\u00edneos a partir de otros preexistentes se denomina angiog\u00e9nesis. Sobre este proceso, el factor de crecimiento transformante-beta (tfg-beta) es una citoquina que juega un papel dual, ejerciendo funciones tanto pro-angiog\u00e9nicas como anti angiog\u00e9nicas. En esta tesis doctoral se ha demostrado que endoglina, receptor auxiliar de tgf-beta, altamente expresado en c\u00e9lulas endoteliales, es capaz de promover la fase de activaci\u00f3n de la angiog\u00e9nesis en respuesta a tgf-beta. Se ha obtenido que es capaz de interaccionar con alk-1, receptor tipo i de tgf-beta expresado predominantemente en c\u00e9lulas endoteliales.  esta asociaci\u00f3n f\u00edsica tiene lugar tanto a nivel extracelular como citopl\u00e1smico y resulta en una cooperaci\u00f3n funcional sobre su v\u00eda de se\u00f1alizaci\u00f3n, esto es, a trav\u00e9s de samd1. Se inducen as\u00ed fen\u00f3menos como proliferaci\u00f3n celular y la inducci\u00f3n de genes espec\u00edficos como ld1. Por el contrario, endoglina es capaz de bloquear la v\u00eda de se\u00f1alizaci\u00f3n de tfg-beta a trav\u00e9s del ampliamente expresado receptor tipo i, denominado alk-5, mediante smad3.     por otra parte, se ha observado que cuando las c\u00e9lulas endoteliales entran a senescencia, hay un cambio en la expresi\u00f3n de la isoforma endoglina, gener\u00e1ndose una prote\u00edna m\u00e1s corta denominada endoglina-s. Esta isoforma es capaz de interaccionar con ambos receptores tipo i de tgf-beta pero con una afinidad muy mayor por alk-5. El resultado de la expresi\u00f3n de endoglina-l. Endoglina-s favorece la v\u00eda de se\u00f1alizaci\u00f3n alk-5\/smad3 en detrimento de la de alk-1\/smad, reflej\u00e1ndose en un aumento de la actividad transcripcional del promotor de pai-1 y disminuci\u00f3n del de ld1, respectivamente.     adem\u00e1s, se ha demostrado que alk-1 se localiza en unos microdominios especializados de la membrana<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de endoglina y alk-1 en la v\u00edade se\u00f1alizaci\u00f3n de tgf-beta<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de endoglina y alk-1 en la v\u00edade se\u00f1alizaci\u00f3n de tgf-beta <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier Blanco L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmelo Bernabeu Quirante<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Guzm\u00e1n pastor <\/li>\n<li>Marta Saura redondo (vocal)<\/li>\n<li>Miguel Quintanilla avila (vocal)<\/li>\n<li>Carlos Caba\u00f1as guti\u00e9rrez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier Blanco L\u00f3pez El endotelio vascular es una monocapa de c\u00e9lulas que tapiza el interior de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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