{"id":54924,"date":"2006-06-10T00:00:00","date_gmt":"2006-06-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-de-riesgo-cardiovascular-en-ninos-prepuberes-con-estatura-baja-y-tratamiento-con-hormona-de-crecimiento-gh-valoracion-de-la-terapia-sustantiva-con-gh\/"},"modified":"2006-06-10T00:00:00","modified_gmt":"2006-06-10T00:00:00","slug":"factores-de-riesgo-cardiovascular-en-ninos-prepuberes-con-estatura-baja-y-tratamiento-con-hormona-de-crecimiento-gh-valoracion-de-la-terapia-sustantiva-con-gh","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pediatria\/factores-de-riesgo-cardiovascular-en-ninos-prepuberes-con-estatura-baja-y-tratamiento-con-hormona-de-crecimiento-gh-valoracion-de-la-terapia-sustantiva-con-gh\/","title":{"rendered":"Factores de riesgo cardiovascular en ni\u00f1os prep\u00faberes con estatura baja y tratamiento con hormona de crecimiento (gh): valoraci\u00f3n de la terapia sustantiva con gh"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Adela S\u00e1nchez Carri\u00f3n <\/strong><\/h2>\n<p>La asociaci\u00f3n entre el d\u00e9ficit de hormona de crecimiento gh y el desarrollo de factores de riesgo cardiovascular ha sido ampliamente descrita en adultos, pero hasta la fecha, son escasos los trabajos que han estudiado si esta asociaci\u00f3n ya est\u00e1 presente en la etapa prepuberal en ni\u00f1os con estatura baja y d\u00e9ficit de gh, y si la terapia sustitutiva con dicha hormona es capaz de revertir en ellos estos factores de riesgo.     con este fin, realizamos un estudio observacional prospectivo de 6 meses de seguimiento, en 36 ni\u00f1os con estatura baja y d\u00e9ficit de gh (dgh), que fueron tratados con esta hormona, y un grupo control de similar \u00edndice de masa corporal, formado por 38 ni\u00f1os sanos. todos los participantes en el estudio eran prep\u00faberes (estad\u00edo i de tanner).     despu\u00e9s de analizar par\u00e1metros antropom\u00e9tricos y bioqu\u00edmicos relacionados con el riesgo cardiovascular de forma basal en ambos grupos y nuevamente en el grupo con dgh tras 6 meses de tratamiento hormonal sustitutivo, se observ\u00f3 que los ni\u00f1os con dgh prestaban basalmente niveles significativamente m\u00e1s elevados de colesterol total, ldl colesterol, triglic\u00e9ridos, apolipoprote\u00edna b (apo b), pai-1 (inhibidor del activador del plasmin\u00f3geno tipo 1), fibrin\u00f3geno e icam-i (mol\u00e9cula de adhesi\u00f3n intercelular tipo 1) y que tras el tratamiento, se produjo un aumento estad\u00edsticamente significativo en los niveles de igf-i, insulina e \u00edndice homa, as\u00ed como un descenso en los niveles de pai-1. Los valores de colesterol total, ldl colesterol, apo e e icam-1 tambi\u00e9n tendieron a disminuir sin llegar a ser significativo.     seg\u00fan los resultados obtenidos, podemos concluir que los ni\u00f1os con estatura baja y dgh, antes de iniciar el tratamiento de reemplazo, ya presentan a edades prep\u00faberes muchas de las alteraciones metab\u00f3licas descritas en adultos, como la alteraci\u00f3n del metabolismo lip\u00eddico, el trastorno de la fibrinolisis y la coagulaci\u00f3n o la disfunci\u00f3n endotelial vascular, que los pr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores de riesgo cardiovascular en ni\u00f1os prep\u00faberes con estatura baja y tratamiento con hormona de crecimiento (gh): valoraci\u00f3n de la terapia sustantiva con gh<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores de riesgo cardiovascular en ni\u00f1os prep\u00faberes con estatura baja y tratamiento con hormona de crecimiento (gh): valoraci\u00f3n de la terapia sustantiva con gh <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Adela S\u00e1nchez Carri\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ram\u00f3n Ca\u00f1ete Estrada<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Jimenez reina <\/li>\n<li>ricardo Gracia bouthelier (vocal)<\/li>\n<li>montserrat Anton gamero (vocal)<\/li>\n<li> Rodriguez arnao Mar\u00eda  dolores (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Adela S\u00e1nchez Carri\u00f3n La asociaci\u00f3n entre el d\u00e9ficit de hormona de crecimiento gh y el desarrollo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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