{"id":54941,"date":"2006-06-10T00:00:00","date_gmt":"2006-06-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudi-de-la-interaccio-del-pa%c2%a8ptid-de-fusio-de-la-protea%c2%afna-gp41-del-vih-amb-membranes-model\/"},"modified":"2006-06-10T00:00:00","modified_gmt":"2006-06-10T00:00:00","slug":"estudi-de-la-interaccio-del-pa%c2%a8ptid-de-fusio-de-la-protea%c2%afna-gp41-del-vih-amb-membranes-model","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudi-de-la-interaccio-del-pa%c2%a8ptid-de-fusio-de-la-protea%c2%afna-gp41-del-vih-amb-membranes-model\/","title":{"rendered":"Estudi de la interacci\u00f3 del p\u00e9ptid de fusi\u00f3 de la prote\u00c1\u00afna gp41 del vih amb membranes model"},"content":{"rendered":"<h2>Tesis doctoral de <strong> V\u00edctor Buz\u00f3n Redorta <\/strong><\/h2>\n<p>El virus de la inmunodeficiencia humana, vih, es un virus con membrana de la familia retroviridae. El primer paso en el proceso de infecci\u00f3n es su entrada en la c\u00e9lula hu\u00e9ped. En el caso de la infecci\u00f3n de linfocitos t, primero se produce el reconocimiento del receptor cd4 por parte de la prote\u00edna gp120 del virus. Esta prote\u00edna est\u00e1 unida mediante interacciones d\u00e9biles con otra prote\u00edna de la membrana l\u00edpidica del virus, la prote\u00edna gp41. \u00e9sta es la responsable final del proceso final de la fusi\u00f3n entre la membrana plasm\u00e1tica de la c\u00e9lula hu\u00e9sped y la membrana l\u00edpidica del virus, permitiendo la entrada de este \u00faltimo en el citoplasma de la c\u00e9lula e iniciando as\u00ed el proceso de infecci\u00f3n. la prote\u00edna gp41 presenta en su extremo amino terminal una secuencia muy hidrof\u00f3bica y rica en residuos de glicina y alanina y que se conoce como p\u00e9ptido de fusi\u00f3n. Una vez producido el reconocimiento, la gp120 sufre un cambio conformacional que se transmite a la gp41, de manera que el p\u00e9ptido de fusi\u00f3n interacciona con la membrana del linfocito, desencadenando el proceso de fusi\u00f3n. en el presente trabajo se ha estudiado la interacci\u00f3n de p\u00e9ptidos de fusi\u00f3n de la prote\u00edna gp41 del vih con membranas modelo. Los resultados obtenidos han permitido proponer un modelo cin\u00e9tico de los diferentes procesos que tienen lugar durante la interacci\u00f3n de estos p\u00e9ptidos con membranas modelo, contribuyendo de manera remarcable a resolver una cuesti\u00f3n hasta el momento controvertida, referente al tipo de estructura que adopta el p\u00e9ptido de fusi\u00f3n cuando interacciona con las membranas y que desencadena la fusi\u00f3n. El trabajo tambi\u00e9n ha permitido determinar la importancia del potencial dipolar de membrana, un par\u00e1metro f\u00edsico-qu\u00edmico de las membranas en estos procesos, as\u00ed como la importancia de la presencia de colesterol en las membranas modelo.  seg\u00fan los resultados obtenidos, el p\u00e9ptido de fusi\u00f3n primero interaccionar\u00eda con la membrana. Un vez unido a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudi de la interacci\u00f3 del p\u00e9ptid de fusi\u00f3 de la prote\u00c1\u00afna gp41 del vih amb membranes model<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudi de la interacci\u00f3 del p\u00e9ptid de fusi\u00f3 de la prote\u00c1\u00afna gp41 del vih amb membranes model <\/li>\n<li><strong>Autor:<\/strong>\u00a0 V\u00edctor Buz\u00f3n Redorta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josep Cladera Cerd\u00c1\u00a0<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: esteve Padr\u00f3s morell <\/li>\n<li>olga Lopez serrano (vocal)<\/li>\n<li>vict\u00ed\u00b2ria Nogu\u00e9s bara (vocal)<\/li>\n<li>isabel Haro villar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de V\u00edctor Buz\u00f3n Redorta El virus de la inmunodeficiencia humana, vih, es un virus con membrana de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,35,964,969],"tags":[2843,49965,121374,101196,121375,121373],"class_list":["post-54941","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-ciencias-de-la-vida","category-lipidos","category-peptidos","tag-esteve-padros-morell","tag-isabel-haro-villar","tag-josep-cladera-cerda","tag-olga-lopez-serrano","tag-victiria-nogues-bara","tag-victor-buzon-redorta"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54941","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=54941"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54941\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=54941"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=54941"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=54941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}