{"id":55042,"date":"2018-03-09T22:42:44","date_gmt":"2018-03-09T22:42:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacologa%c2%ada-de-terpenoides-de-helianthus-annuus-l\/"},"modified":"2018-03-09T22:42:44","modified_gmt":"2018-03-09T22:42:44","slug":"farmacologa%c2%ada-de-terpenoides-de-helianthus-annuus-l","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacologa%c2%ada-de-terpenoides-de-helianthus-annuus-l\/","title":{"rendered":"Farmacolog\u00eda de terpenoides de helianthus annuus l."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  D\u00edaz Viciedo Rodrigo Eugenio <\/strong><\/h2>\n<p>Desde los albores de la humanidad, las plantas han sido fuentes de inter\u00e9s, tanto por su caracter\u00edsticas nutricionales como medicinales. En base a este paradigma y considerando la l\u00ednea de investigaci\u00f3n que se viene desarrollando desde hace tiempo en el departamento de farmacolog\u00eda de la facultad de la universidad complutense de Madrid, se realiz\u00f3 un estudio farmacol\u00f3gico de terpenoides de la especie vegetal helianthus annuus l., Conocida como girasol. Para ello se optimiz\u00f3 un m\u00e9todo de extracci\u00f3n, aislamiento y purificaci\u00f3n de dichos metabolitos, para posteriormente evaluar una posible actividad farmacol\u00f3gica sobre modelos de inflamaci\u00f3n. Cabe destacar que tambi\u00e9n se determin\u00f3 una potencial actividad de esta naturaleza utilizando dos extractos (metan\u00f3lico y acuoso) de la planta en estudio. Se aislaron tres diterpenos kauranos (\u00e1cido kaurenoico, \u00e1cido traquilob\u00e1nico y \u00e1cido grandiflor\u00f3lico) mediante t\u00e9cnicas cromatogr\u00e1ficas, identific\u00e1ndose su estructura por las t\u00e9cnicas de rmn (1h, 13c) y evaluando su pureza por hplc. Paralelamente se evalu\u00f3 la variaci\u00f3n estacional del \u00e1cido grandiflor\u00f3lico y de la mezcla de \u00e1cido kaurenoico y traquilob\u00e1nico obtenida en un principio, en diferentes partes de la planta durante el periodo de desarrollo de la misma, con el fin de determinar en qu\u00e9 parte de la planta y en qu\u00e9 periodo de tiempo se produce una m\u00e1xima acumulaci\u00f3n del metabolito en estudio, para as\u00ed obtener una extracci\u00f3n con un rendimiento m\u00e1s elevado. Se encontraron diferencias significativas que podr\u00edan ser utilizadas para el control de calidad de preparados a base de plantas medicinales que contengan algunos de estos metabolitos secundarios. Para el estudio de la actividad farmacol\u00f3gica de los terpenoides y de los extractos, se trabaj\u00f3 sobre dos modelos de inflamaci\u00f3n (in vivo e in vitro). En el modelo in vivo se evalu\u00f3 la acci\u00f3n de los compuestos en estudio sobre el edema producido por aplicaci\u00f3n t\u00f3pica de tpa en oreja de r<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacolog\u00eda de terpenoides de helianthus annuus l.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacolog\u00eda de terpenoides de helianthus annuus l. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  D\u00edaz Viciedo Rodrigo Eugenio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1ngel Villar Del Fresno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Mart\u00ednez Fern\u00e1ndez Antonio  R. <\/li>\n<li>\u00e1ngeles Fern\u00e1ndez Arche (vocal)<\/li>\n<li>Victor Jimenez Torres (vocal)<\/li>\n<li>Benjam\u00edn Rodr\u00edguez Gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de D\u00edaz Viciedo Rodrigo Eugenio Desde los albores de la humanidad, las plantas han sido fuentes de inter\u00e9s, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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