{"id":55075,"date":"2018-03-09T22:42:47","date_gmt":"2018-03-09T22:42:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/rutas-de-senalizacion-moduladoras-de-proliferacion-y-diferenciacion-en-calulas-madre-y-precursores-neurales\/"},"modified":"2018-03-09T22:42:47","modified_gmt":"2018-03-09T22:42:47","slug":"rutas-de-senalizacion-moduladoras-de-proliferacion-y-diferenciacion-en-calulas-madre-y-precursores-neurales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/rutas-de-senalizacion-moduladoras-de-proliferacion-y-diferenciacion-en-calulas-madre-y-precursores-neurales\/","title":{"rendered":"Rutas de se\u00f1alizaci\u00f3n moduladoras de proliferaci\u00f3n y diferenciaci\u00f3n en c\u00e1lulas madre y precursores neurales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gaizka Otaegui Garc\u00eda <\/strong><\/h2>\n<p>El control de la neurog\u00e9nesis en el snc implica regular m\u00faltiples procesos celulares, como la proliferaci\u00f3n del os precursores y c\u00e9lulas madre neurales, la diferenciaci\u00f3n y la apoptosis. As\u00ed, las c\u00e9lulas madre neurales del bulbo olfatorio (cmbo) dependen de la (pro)insulina o del igf-i para suproliferaci\u00f3n en cultivo. El igf-i adem\u00e1s promueve la diferenciaci\u00f3n de las cmbo a neuronas y l\u00eda, tanto en cultivo como in vivo. Con objeto de estudiar la posible implicaci\u00f3n de las rutas bioqu\u00edmicas pi3\/akt y map kinasas en la se\u00f1alizaci\u00f3n por factores de la familia de la insulina, las cmbo se trataron durante 30 minutos con igf-i. Hemos visto que esta prote\u00edna estimula notablemente la fosforilaci\u00f3n de akt tanto en la fase de proliferaci\u00f3n como de diferenciaci\u00f3n de las cmbo, mientras que no activa significativamente erk1\/erk2. La importancia de la ruta bioqu\u00edmica de pi3k\/akt se comprob\u00f3 mediante la sobreexpresi\u00f3n, utilizando construcciones retrovirales, en estas c\u00e9lulas de la fosfatasa pten, un inhibidor de dicha ruta. El aumento de pten provoc\u00f3 una disminuci\u00f3n en los niveles basales de pakt\/akt y adem\u00e1s una reducci\u00f3n del n\u00famero de neuronas y astrocitos derivados de las cmbo, pero no alter\u00f3 su proliferaci\u00f3n. Finalmente, para comprobar el efecto de la ausencia del igf-i end\u00f3geno sobre la activaci\u00f3n de akt, hemos cuantificado esta prote\u00edna en bo de embriones knockout para igf-i a diferentes edades. Nuestros datos muestran una disminuci\u00f3n significativa delos niveles de pakt\/akt en el bo de ratones nulos para igf-1 a la edad de e16,5-e18,5. por tanto, durante la neurog\u00e9nesis del bulbo olfatorio, igf-i activa la ruta de se\u00f1alizaci\u00f3n de pi3k\/akt, siendo pten una mol\u00e9cula clave para la regulaci\u00f3n de la diferenciaci\u00f3n celular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Rutas de se\u00f1alizaci\u00f3n moduladoras de proliferaci\u00f3n y diferenciaci\u00f3n en c\u00e1lulas madre y precursores neurales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Rutas de se\u00f1alizaci\u00f3n moduladoras de proliferaci\u00f3n y diferenciaci\u00f3n en c\u00e1lulas madre y precursores neurales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gaizka Otaegui Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Pablo D\u00e1vila Flora De<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Fuente m\u00f3nica de la <\/li>\n<li>santos Ma\u00f1es broton (vocal)<\/li>\n<li>ignacio Torres alem\u00e1n (vocal)<\/li>\n<li>isabel Fari\u00f1as g\u00f3mez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gaizka Otaegui Garc\u00eda El control de la neurog\u00e9nesis en el snc implica regular m\u00faltiples procesos celulares, como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,160],"tags":[86460,121661,6465,50973,60560,104999],"class_list":["post-55075","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-bioquimica","tag-fuente-monica-de-la","tag-gaizka-otaegui-garcia","tag-ignacio-torres-aleman","tag-isabel-farinas-gomez","tag-pablo-davila-flora-de","tag-santos-manes-broton"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55075","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=55075"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55075\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=55075"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=55075"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=55075"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}