{"id":55137,"date":"2018-03-09T22:42:51","date_gmt":"2018-03-09T22:42:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismo-de-accion-a-nivel-molecular-del-tungstato-de-sodio-un-agente-antidiabetico\/"},"modified":"2018-03-09T22:42:51","modified_gmt":"2018-03-09T22:42:51","slug":"mecanismo-de-accion-a-nivel-molecular-del-tungstato-de-sodio-un-agente-antidiabetico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/mecanismo-de-accion-a-nivel-molecular-del-tungstato-de-sodio-un-agente-antidiabetico\/","title":{"rendered":"Mecanismo de acci\u00f3n a nivel molecular del tungstato de sodio, un agente antidiab\u00e9tico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Delia Zafra L\u00f3pez <\/strong><\/h2>\n<p>Existen numerosos estudios sobre los efectos antidiab\u00e9ticos del tungstato de sodio en diferentes modelos animales de diabetes tipo 1 y tipo 2. Sin embargo, antes del inicio de esta tesis doctoral no se hab\u00eda investigado el mecanismo de acci\u00f3n a nivel molecular de este compuesto. puesto que los modelos animales estudiados el tungstato de sodio ejerce sus efectos sobre los mismos tejidos sobre los que act\u00faa la insulina, nuestra hip\u00f3tesis de trabajo era que el tungstato de sodio podr\u00eda estar actuando sobre alguno de los componentes de la cascada de se\u00f1alizaci\u00f3n de esta hormona. Mediante an\u00e1lisis de fosforilaci\u00f3n por western blot y ensayos de actividad quinasa comprobamos que el tratamiento con tungstato de sodio, tanto en c\u00e9lulas choir (un modelo ideal para el estudio de la cascada de se\u00f1alizaci\u00f3n de la insulina) como en cultivos primarios de hepatocitos (un sistema m\u00e1s cercano al fisiol\u00f3gico), activa la v\u00eda de ras\/raf\/mek\/erk a trav\u00e9s de un mecanismo independiente de la fosforilaci\u00f3n del receptor de insulina. esta activaci\u00f3n de la v\u00eda mitog\u00e9nica conduce a una fosforilaci\u00f3n de gsk3 independiente de la activaci\u00f3n de la v\u00eda de pl3k-pdk1-pkb\/akt pero dependiente de erk y probablemente de p90rsk. Adem\u00e1s, tanto la pkc como prote\u00ednas g sensibles a toxina pert\u00fasica est\u00e1n implicadas en el mecanismo de acci\u00f3n del tungstato, puesto que la inhibici\u00f3n de estas prote\u00ednas bloquea los efectos del tungstato sobre la activaci\u00f3n de la v\u00eda mitog\u00e9nica. En cultivos primarios de hepatocitos tanto la activaci\u00f3n de erk1\/2 como las prote\u00ednas g son necesarias para la posterior estimulaci\u00f3n de la s\u00edntesis de gluc\u00f3geno observada en respuesta a tungstato en estas c\u00e9lulas. Finalmente, el tratamiento de ratas diab\u00e9ticas por inyecci\u00f3n de estreptozotocina con tungstato normaliza la fosforilaci\u00f3n de algunas prote\u00ednas de la cascada de se\u00f1alizaci\u00f3n de la insulina, as\u00ed como la expresi\u00f3n de algunas prote\u00ednas cuyos niveles se encuentran alterados por la dia<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismo de acci\u00f3n a nivel molecular del tungstato de sodio, un agente antidiab\u00e9tico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismo de acci\u00f3n a nivel molecular del tungstato de sodio, un agente antidiab\u00e9tico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Delia Zafra L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Guinovart Cirera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Fel\u00edu albi\u00f1ana Juan  e. <\/li>\n<li>ramon Gomis de barbar? (vocal)<\/li>\n<li>margarita Lorenzo balado (vocal)<\/li>\n<li> Rodr\u00edguez gil joan e. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Delia Zafra L\u00f3pez Existen numerosos estudios sobre los efectos antidiab\u00e9ticos del tungstato de sodio en diferentes modelos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,36483,9399],"tags":[121797,102282,13699,42261,1375,121798],"class_list":["post-55137","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-biologia-molecular","category-cultivo-celular","tag-delia-zafra-lopez","tag-feliu-albinana-juan-e","tag-joan-guinovart-cirera","tag-margarita-lorenzo-balado","tag-ramon-gomis-de-barbar","tag-rodriguez-gil-joan-e"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=55137"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55137\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=55137"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=55137"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=55137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}