{"id":55139,"date":"2018-03-09T22:42:51","date_gmt":"2018-03-09T22:42:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/trasplante-de-progenitores-hematopoyeticos-en-la-leucemia-linfatica-cronica-impacto-pronostico-y-significado-biologico\/"},"modified":"2018-03-09T22:42:51","modified_gmt":"2018-03-09T22:42:51","slug":"trasplante-de-progenitores-hematopoyeticos-en-la-leucemia-linfatica-cronica-impacto-pronostico-y-significado-biologico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/trasplante-de-progenitores-hematopoyeticos-en-la-leucemia-linfatica-cronica-impacto-pronostico-y-significado-biologico\/","title":{"rendered":"Trasplante de progenitores hematopoy\u00e9ticos en la leucemia linf\u00e1tica cr\u00f3nica: impacto pron\u00f3stico y significado biol\u00f3gico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carolina Moreno Atanasio <\/strong><\/h2>\n<p>La leucemia linf\u00e1tica cr\u00f3nica (llc), la leucemia m\u00e1s frecuente en los pa\u00edses occidentales, es un s\u00edndrome linfoproliferativo que se caracteriza por la acumulaci\u00f3n progresiva de linfocitos maduros de estirpe b y cd5+ en tejidos linfoides, m\u00e9dula \u00f3sea y sangre perif\u00e9rica. El curso de la enfermedad es extremadamente variable. Las mutaciones de los genes de las igvh distinguen dos formas distintas de la enfermedad con respecto al pron\u00f3stico, de tal forma que los pacientes con formas \u00abno mutadas\u00bb, de la enfermedad tienen peor pron\u00f3stico que aquellos con la variedad \u00abmutada\u00bb. Este hecho es independiente del tipo de tratamiento. en la actualidad, el tratamiento con an\u00e1logos de las purinas en combinaci\u00f3n con otros agentes y los trasplantes de progenitores hematopoy\u00e9ticos, permiten alcanzar un 60-80% de rc. Adem\u00e1s, muchas de estas rc se acompa\u00f1an de la erradicaci\u00f3n de la erm. Por ello, en el estudio de la erm en la llc, su significado cl\u00ednico e implicaciones terap\u00e9uticas est\u00e1 cobrando gran inter\u00e9s. sin embargo, a pesar de algunos avances en el tratamiento de la llc, esta enfermedad contin\u00faa siendo incurable. este hecho, junto con el diagn\u00f3stico cada vez m\u00e1s frecuente de esta forma de leucemia en pacientes a\u00fan j\u00f3venes y, las dificultades que plantea el tratamiento de los enfermos que recaen o son resistentes a los actuales tratamientos, hace que sean cada vez m\u00e1s los enfermos en los que se plantea un trasplante de progenitores hematopoy\u00e9ticos.     esta tesis doctoral se basa en trabajos de investigaci\u00f3n que se centran en el papel del trasplante de progenitores hematopoy\u00e9ticos en el tratamiento de los pacientes con llc.     las hip\u00f3tesis de trabajo fueron las siguientes:     1,- el trasplante alog\u00e9nico de progenitores hematopoy\u00e9ticos en los pacientes con llc podr\u00eda eliminar el significado pron\u00f3stico negativo de algunos par\u00e1metros, particularmente la ausencia de mutaciones en lso genes de las igvh, en estos enfermos.     2,- el an<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Trasplante de progenitores hematopoy\u00e9ticos en la leucemia linf\u00e1tica cr\u00f3nica: impacto pron\u00f3stico y significado biol\u00f3gico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Trasplante de progenitores hematopoy\u00e9ticos en la leucemia linf\u00e1tica cr\u00f3nica: impacto pron\u00f3stico y significado biol\u00f3gico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carolina Moreno Atanasio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emili Montserrat Costa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ciril Roman borstnar <\/li>\n<li>josep Riebera santasusana (vocal)<\/li>\n<li>anna Aventin artisan (vocal)<\/li>\n<li>francesc Cardellach l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carolina Moreno Atanasio La leucemia linf\u00e1tica cr\u00f3nica (llc), la leucemia m\u00e1s frecuente en los pa\u00edses occidentales, es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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