{"id":55149,"date":"2018-03-09T22:42:51","date_gmt":"2018-03-09T22:42:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/lipoapoptosis-inducida-por-acidos-grasos-de-la-dieta-en-celulas-beta-ins1\/"},"modified":"2018-03-09T22:42:51","modified_gmt":"2018-03-09T22:42:51","slug":"lipoapoptosis-inducida-por-acidos-grasos-de-la-dieta-en-celulas-beta-ins1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/lipoapoptosis-inducida-por-acidos-grasos-de-la-dieta-en-celulas-beta-ins1\/","title":{"rendered":"Lipoapoptosis inducida por acidos grasos de la dieta en celulas beta (ins1)"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Maestre Lopez Mar\u00eda  Isabel <\/strong><\/h2>\n<p>La diabetes tipo 2 es una enfermedad multifactiorial en la que convergen diversos determinantes. Entre estos, el exceso de nutrientes calorin\u00e9rgicos ha sido uno de los factores m\u00e1s estudiados. En un principio los estudios se centraron sobre la glucosa, pero recientemente el desarrollo de la diabetes tipo 2 se ha adscrito a la presencia de concentraciones elevadas de \u00e1cidos grasos en circulaci\u00f3n. Por ello se ha acu\u00f1ado el t\u00e9rmino de lipotoxicidad. Se sabe que con el tiempo se produce una disfunci\u00f3n en la c\u00e9lula beta pancre\u00e1tica que culmina en la muerte de este tipo celular. Los mecanismos moleculares que median este proceso son todav\u00eda desconocidos, pero su caracterizaci\u00f3n podr\u00eda ayudar a desarrollar estrategias farmacol\u00f3gicas para retrasar el desarrollo de la patolog\u00eda. Utilizado un sistema de c\u00e9lulas cultivadas, la presente tesis ha descifrado algunos de los mecanismos que operan en este proceso. Se ha podido ver que una exposici\u00f3n prolongada de c\u00e9lulas beta a concentraciones elevadas de \u00e1cidos grasos resulta en la inducci\u00f3n de alteraciones a nivel mitocondrial: p\u00e9rdida del potencial de membrana, generaci\u00f3n de radical super\u00f3xido, liberaci\u00f3n de citocromo c y aif y acumulaci\u00f3n de la prote\u00edna pro-apopt\u00f3tica bax. Todo ello desencadena un proceso de muerte celular programada caracterizado por la presencia de ciclos celulares aberrantes, condensaci\u00f3n de la cromatina, fragmentaci\u00f3n del adn. No observamos participaci\u00f3n de la ruta de la \u00f3xido n\u00edtrico sintetasa inducible ni de ceramidas, al menos para el caso del oleato. El proceso viene precedido de la activaci\u00f3n de genes tempranos, como c-fos y nur-77, que pueden mediar procesos apopt\u00f3ticos en diversos tipos celulares. En conclusi\u00f3n, la presencia persistente de concentraciones elevadas de \u00e1cidos grasos de la dieta puede sobrepasar la respuesta adaptativa de la c\u00e9lula beta pancre\u00e1tica y conducir a su destrucci\u00f3n por procesos apopt\u00f3ticos, resultando en una ausencia de insulina y desarro<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Lipoapoptosis inducida por acidos grasos de la dieta en celulas beta (ins1)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Lipoapoptosis inducida por acidos grasos de la dieta en celulas beta (ins1) <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Maestre Lopez Mar\u00eda  Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Roche Collado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Antonio Reig maci\u00e1 <\/li>\n<li>joaqu\u00edn Jord\u00e1n bueso (vocal)<\/li>\n<li>guillermina Asins mu\u00f1oz (vocal)<\/li>\n<li>Elena Garcia garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Maestre Lopez Mar\u00eda Isabel La diabetes tipo 2 es una enfermedad multifactiorial en la que convergen diversos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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