{"id":55174,"date":"2018-03-09T22:42:55","date_gmt":"2018-03-09T22:42:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-funcion-del-coactivador-pgc-1-alpha-en-la-regulacion-del-sistemaantioxidante-mitocondrial-en-celulas-endoteliales\/"},"modified":"2018-03-09T22:42:55","modified_gmt":"2018-03-09T22:42:55","slug":"estudio-de-la-funcion-del-coactivador-pgc-1-alpha-en-la-regulacion-del-sistemaantioxidante-mitocondrial-en-celulas-endoteliales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-la-funcion-del-coactivador-pgc-1-alpha-en-la-regulacion-del-sistemaantioxidante-mitocondrial-en-celulas-endoteliales\/","title":{"rendered":"Estudio de la funci\u00f3n del coactivador pgc-1 alpha en la regulaci\u00f3n del sistemaantioxidante mitocondrial en c\u00e9lulas endoteliales"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Valle Asencio Mar\u00eda Inmaculada <\/strong><\/h2>\n<p>Las complicaciones vasculares asociadas a la diabetes se inician con una alteraci\u00f3n de las propiedades fisiol\u00f3gicas del endotelio conocida como disfunci\u00f3n endotelial. Se han propuesto como responsables del origen y desarrollo de la disfunci\u00f3n endotelial a los niveles elevados de glucosa, y m\u00e1s concretamente el estr\u00e9s oxidativo derivado de su metabolizaci\u00f3n a nivel de la mitocondria. a lo largo del presente estudio mostraremos como pgc-1 alpha (peroxisome activated receptor gamma coactivador 1 alpha), considerado como el principal regulador del metabolismo oxidativo, controla de forma coordinada los niveles de expresi\u00f3n del sistema mitocondrial de detoxificaci\u00f3n de especies oxidantes (ros) en c\u00e9lulas endoteliales. La activaci\u00f3n transcripcional de este sistema de defensa pro parte de pgc-1 alpha se traduce en la disminuci\u00f3n de los ros acumulados en la c\u00e9lula endotelial, evita la disfunci\u00f3n mitocondrial y reduce la muerte celular por apoptosis, tanto en condiciones basales como de estr\u00e9s oxidativo (niveles elevados de glucosa en el medio). la regulaci\u00f3n transcripcional de la maquinaria de protecci\u00f3n frente a estr\u00e9s oxidativo mitocondrial se ejerce a trav\u00e9s de un complejo proteico en el que junto con pgc-1 alpha encontramos a foxo3a. proponemos que este factor de transcripci\u00f3n media el efecto protector de pgc-1 alpha a trav\u00e9s del reconocimiento y asociaci\u00f3n a sus secuencias de uni\u00f3n en los promotores de los genes del sistema de defensa. los resultados obtenidos revelan la existencia de un mecanismo de regulaci\u00f3n capaz de coordinar la actividad mitocondrial y la maquinaria encargada de la eliminaci\u00f3n de las especies oxidantes derivadas del metabolismo mitocondrial. la regulaci\u00f3n de la actividad del complejo pgc-1alpha7foxo3a, o de cada uno de sus integrantes independientemente, podr\u00eda actuar protegiendo al endotelio de los efectos negativos de la hiperglicemia y evitar as\u00ed el desarrollo de patolog\u00edas vasculares.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la funci\u00f3n del coactivador pgc-1 alpha en la regulaci\u00f3n del sistemaantioxidante mitocondrial en c\u00e9lulas endoteliales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la funci\u00f3n del coactivador pgc-1 alpha en la regulaci\u00f3n del sistemaantioxidante mitocondrial en c\u00e9lulas endoteliales <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Valle Asencio Mar\u00eda Inmaculada <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Santiago Lamas Pel\u00e1ez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ana Aranda iriarte <\/li>\n<li>francesc Villarroya gombau (vocal)<\/li>\n<li> Botella cubells Luisa Mar\u00eda (vocal)<\/li>\n<li>eva Cano l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Valle Asencio Mar\u00eda Inmaculada Las complicaciones vasculares asociadas a la diabetes se inician con una alteraci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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