{"id":5520,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/obtencion-de-anticuerpos-monoclonales-contra-el-complejo-antigenico-reconocido-por-las-celulas-nk\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"obtencion-de-anticuerpos-monoclonales-contra-el-complejo-antigenico-reconocido-por-las-celulas-nk","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/obtencion-de-anticuerpos-monoclonales-contra-el-complejo-antigenico-reconocido-por-las-celulas-nk\/","title":{"rendered":"Obtencion de anticuerpos monoclonales contra el complejo antigenico reconocido por las celulas nk."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sarandeses Da Costa Concepcion Sofia <\/strong><\/h2>\n<p>Las celulas nk son una poblacion heterogenea de linfocitos que ejercen una actividad citotoxica no mediada por la presencia de moleculas de mhc en las celulas diana. Aun no se conocen las moleculas capaces de desencadenar el avento litico. En el presente trabajo hemos obtenido mabs (ce35, ch35,ha18 y hh11) contra antigenos de superficie de las celulas diana nc-37. Estos mabs interaccionan con receptores presentes en las celulas diana nc-37, k562 y daudi, provocando inhibicion de la actividad litica mediada por las celulas nk. Este efecto inhibitorio se produce una vez que ha tenido lugar el reconocimiento entre las celula nk y su diana. La concentracion relativa de receptores para ce35, ch35, ha18 y hh11 se estudio por citometria de flujo mostrando diferentes niveles de union en las celulas analizadas.  las caracteristicas moleculares del antigeno reconocido por los mabs se estudiaron mediante ensayos de inmunoprecipitacion. El anticuerpo ha18 reconoce un antigeno conformacional constituido por tres polipeptidos de 31, 35 y 42 kda unidos entre si por puentes disulfuro, para formar una molecula compleja de 200 kda, como demuestran los resultados realizados en ausencia de agentes reductores. Esta estructura no se corresponde con ninguna conocida por lo que podria ser un nuevo receptor de las celulas nk.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Obtencion de anticuerpos monoclonales contra el complejo antigenico reconocido por las celulas nk.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Obtencion de anticuerpos monoclonales contra el complejo antigenico reconocido por las celulas nk. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sarandeses Da Costa Concepcion Sofia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Montserrat Nogueira Alvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Germ\u00e1n Sierra Marcu\u00f1o <\/li>\n<li>Luis Blanco D\u00e1vila (vocal)<\/li>\n<li>Francisco Gambon Deza (vocal)<\/li>\n<li>Isabel Bernardez Hermida (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sarandeses Da Costa Concepcion Sofia Las celulas nk son una poblacion heterogenea de linfocitos que ejercen una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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