{"id":55233,"date":"2018-03-09T22:42:58","date_gmt":"2018-03-09T22:42:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/actividad-antifungica-de-las-equinocandinas-estudio-especa%c2%adfico-de-la-caspofungina\/"},"modified":"2018-03-09T22:42:58","modified_gmt":"2018-03-09T22:42:58","slug":"actividad-antifungica-de-las-equinocandinas-estudio-especa%c2%adfico-de-la-caspofungina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/actividad-antifungica-de-las-equinocandinas-estudio-especa%c2%adfico-de-la-caspofungina\/","title":{"rendered":"Actividad antif\u00fangica de las equinocandinas. estudio espec\u00edfico de la caspofungina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00f3nica Romero Otero <\/strong><\/h2>\n<p>La caspofungina, aislada de glarea lozoyensis, es un antif\u00fangico lipop\u00e9ptidico del grupo de las equinocandinas que interfiere con la s\u00edntesis de glucano mediante la inhibici\u00f3n del complejo de la beta-1,3-d-glucano sintasa. se estudi\u00f3 su actividad antif\u00fangica in vitro sobre levaduras y hongos filamentosos. Se incluyeron 190 cepas de levaduras de origen cl\u00ednico (46 c. Albicans,  42 c. Tropicalis, 32 c. Glabrata, 21 c. Krusei, 20 c. Parapsilosis, 11 c. Guilliermondii, 4 c. Famata, 3 c. Lusitaniae, 3 b. Capitatus, 2  s. Cerevisiae, 2 y. Lipolytica, 1 c. Inconspicua, 1 c. Lambica, 1 c. Sake y 1 p. Ohmeri), nueve cepas de c. Albicans de la colecci\u00f3n msd (algunas de ellas con sensibilidad disminuida a la caspofungina por mutaci\u00f3n en el gen fks1, diana de los inhibidores de la beta-1,3-d-glucano sintasa) y seis cepas atcc con sensibilidad disminuida a la anfotericina b (4 c. Lusitaniae, 1 c. Albicans y 1 c. Tropicalis). Como control de calidad se utiliz\u00f3 c. Krusei atcc 6258. En el apartado de hongos filamentosos se incluyeron 45 cepas de origen cl\u00ednico (25 a. Fumigatus y 20 a. Flavus) y como control de calidad a. Fumigatus atcc 204305 y a. Flavus atcc 204304. las pruebas de sensibilidad in vitro se realizaron mediante los m\u00e9todos estandarizados de microdiluci\u00f3n en placa del clsi (m27-a2 para levaduras y m38-a para hongos filamentosos) y del eucast para levaduras. Los criterios de punto final fueron la cmi2 y la cmi0 en las levaduras y la cme y la cmi0 en los hongos filamentosos. Se estudi\u00f3 la influencia del m\u00e9todo, medio de cultivo, tiempo de incubaci\u00f3n y tipo de lectura sobre la actividad de la caspofungina. se defini\u00f3 el efecto parad\u00f3jico como la aparici\u00f3n de ligero crecimiento en alguno de los pocillos a concentraciones superiores a la cmi0. la actividad de la caspofungina se compar\u00f3 con la actividad de la anfotericina b (en levaduras y hongos filamentosos) y con la del itraconazol y el voriconazol (en hongos filamentosos). la actividad fungicida<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Actividad antif\u00fangica de las equinocandinas. estudio espec\u00edfico de la caspofungina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Actividad antif\u00fangica de las equinocandinas. estudio espec\u00edfico de la caspofungina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00f3nica Romero Otero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilia Canton Lacasa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Gobernado serrano <\/li>\n<li>joaqu\u00edn G\u00f3mez g\u00f3mez (vocal)<\/li>\n<li>rosa Bl\u00e1zquez garrido (vocal)<\/li>\n<li>Jos\u00e9 pedro Martinez garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00f3nica Romero Otero La caspofungina, aislada de glarea lozoyensis, es un antif\u00fangico lipop\u00e9ptidico del grupo de las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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