{"id":55268,"date":"2018-03-09T22:42:58","date_gmt":"2018-03-09T22:42:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudi-de-les-rutes-apoptotiques-mediades-per-la-inhibicio-del-complex-i-mitocondrial-en-ca%c2%a8l-lules-granulars-de-cerebel-de-rata\/"},"modified":"2018-03-09T22:42:58","modified_gmt":"2018-03-09T22:42:58","slug":"estudi-de-les-rutes-apoptotiques-mediades-per-la-inhibicio-del-complex-i-mitocondrial-en-ca%c2%a8l-lules-granulars-de-cerebel-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/estudi-de-les-rutes-apoptotiques-mediades-per-la-inhibicio-del-complex-i-mitocondrial-en-ca%c2%a8l-lules-granulars-de-cerebel-de-rata\/","title":{"rendered":"Estudi de les rutes apopt\u00f3tiques mediades per la inhibici\u00f3 del complex i mitocondrial en c\u00e9l.lules granulars de cerebel de rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Daniel Alvira Aguilera <\/strong><\/h2>\n<p>En los \u00faltimos a\u00f1os, el aumento en la esperanza de vida de la poblaci\u00f3n ha hecho incrementar la incidencia de las enfermedades neurodegenerativas, convirti\u00e9ndose en uno de los principales problemas sanitarios de la sociedad actual. La muerte neuronal puede desencadenarse a trav\u00e9s de diferentes procesos celulares, desencadenando enfermedades como el parkinson o el alzheimer. Una caracter\u00edstica com\u00fan de estas enfermedades son las alteraciones de la mitocondria. La integridad de este org\u00e1nulo es imprescindible para el mantenimiento del as funciones y la supervivencia de las neuronas. Por lo tanto, resulta de gran inter\u00e9s la utilizaci\u00f3n de modelos experimentales in vitro que nos permitan estudiar los mecanismos a trav\u00e9s de los cuales la alteraci\u00f3n de la mitondria induce la muerte apopt\u00f3tica, as\u00ed como intentar descubrir nuevos f\u00e1rmacos que retrasen o paren la degeneraci\u00f3n neuronal. En este trabajo hemos utilizado el i\u00f3n mpp+, un inhibidor del complejo i mitocondrial, para estudiar las rutas y se\u00f1ales intracelulares implicadas en las alteraciones de la mitocondria que inducen apoptosis en un modelo experimental de c\u00e9lulas granulares de cerebelo de rata.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudi de les rutes apopt\u00f3tiques mediades per la inhibici\u00f3 del complex i mitocondrial en c\u00e9l.lules granulars de cerebel de rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudi de les rutes apopt\u00f3tiques mediades per la inhibici\u00f3 del complex i mitocondrial en c\u00e9l.lules granulars de cerebel de rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Daniel Alvira Aguilera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antoni Camins Espuny<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jordi Camarasa garcia <\/li>\n<li>Francisco Javier Sureda batlle (vocal)<\/li>\n<li>coral Sanfeli\u00fa pujol (vocal)<\/li>\n<li>miquel Vila bover (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daniel Alvira Aguilera En los \u00faltimos a\u00f1os, el aumento en la esperanza de vida de la poblaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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