{"id":55276,"date":"2018-03-09T22:42:58","date_gmt":"2018-03-09T22:42:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicaciones-funcionales-de-la-modificacion-postraduccional-de-protea%c2%adnas-en-residuos-de-cistea%c2%adna-por-la%c2%adpidos\/"},"modified":"2018-03-09T22:42:58","modified_gmt":"2018-03-09T22:42:58","slug":"implicaciones-funcionales-de-la-modificacion-postraduccional-de-protea%c2%adnas-en-residuos-de-cistea%c2%adna-por-la%c2%adpidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/implicaciones-funcionales-de-la-modificacion-postraduccional-de-protea%c2%adnas-en-residuos-de-cistea%c2%adna-por-la%c2%adpidos\/","title":{"rendered":"Implicaciones funcionales de la modificaci\u00f3n postraduccional de prote\u00ednas en residuos de ciste\u00edna por l\u00edpidos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Konstantinos Stamatakis <\/strong><\/h2>\n<p>Muchas de las propiedades de las prote\u00ednas, como su localizaci\u00f3n, funcionalidad y actividad, entre otras, se regulan por medio de las modificaciones postraduciconales. Estas alteraciones en la composici\u00f3n qu\u00edmica de los polip\u00e9ptidos aumenta la complejidad del proteoma de las c\u00e9lulas y su regulaci\u00f3n din\u00e1mica. Entre los diversos tipos de modificaci\u00f3n psotraducional de prote\u00edna se encuentran las modificaciones de ciste\u00ednas por l\u00edpidos, que tienen una especial importancia en la localizaci\u00f3n subcelular y en las interacciones prot\u00e9ina-prote\u00edna. En este trabajo hemos estudiado dos aspectos de estas modificaciones; hemos explorado el papel de la isoprenilaci\u00f3n y palmitoilaci\u00f3n de la gtpasa de bajo peso molecular, rhob, sobre sus niveles de expresi\u00f3n y hemos desarrollado una metodolog\u00eda para la identificaci\u00f3n prote\u00f3mica de dianas de modificaci\u00f3n por l\u00edpidos electr\u00f3filos, utilizando como modelo la 15-desoxi-12,14 -prostaglandina j2. En relaci\u00f3n con este segundo aspecto hemos estudiado los efectos del tratamiento de c\u00e9lulas con l\u00edpidos electr\u00f3filos sobre una de las dianas aqu\u00ed identificadas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaciones funcionales de la modificaci\u00f3n postraduccional de prote\u00ednas en residuos de ciste\u00edna por l\u00edpidos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaciones funcionales de la modificaci\u00f3n postraduccional de prote\u00ednas en residuos de ciste\u00edna por l\u00edpidos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Konstantinos Stamatakis <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/10\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>sala P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cristina Casals carro <\/li>\n<li>vicente Andr\u00e9s Garc\u00eda (vocal)<\/li>\n<li> Paramio gonz\u00e1lez Jes\u00fas Mar\u00eda (vocal)<\/li>\n<li>mercedes Salaices s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Konstantinos Stamatakis Muchas de las propiedades de las prote\u00ednas, como su localizaci\u00f3n, funcionalidad y actividad, entre otras, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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