{"id":55325,"date":"2006-03-11T00:00:00","date_gmt":"2006-03-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-heterociclos-nitrogenados-por-formacion-de-enlaces-c-n-n-n-y-n-s-a-traves-de-procesos-promovidos-por-el-reactivo-de-yodo-hipervalente-pifa\/"},"modified":"2006-03-11T00:00:00","modified_gmt":"2006-03-11T00:00:00","slug":"sa%c2%adntesis-de-heterociclos-nitrogenados-por-formacion-de-enlaces-c-n-n-n-y-n-s-a-traves-de-procesos-promovidos-por-el-reactivo-de-yodo-hipervalente-pifa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-heterociclicos\/sa%c2%adntesis-de-heterociclos-nitrogenados-por-formacion-de-enlaces-c-n-n-n-y-n-s-a-traves-de-procesos-promovidos-por-el-reactivo-de-yodo-hipervalente-pifa\/","title":{"rendered":"S\u00edntesis de heterociclos nitrogenados por formaci\u00f3n de enlaces c-n, n-n y n-s a trav\u00e9s de procesos promovidos por el reactivo de yodo hipervalente pifa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Arkaitz Correa Navarro <\/strong><\/h2>\n<p>El presente trabajo de tesis doctoral ha pretendido contribuir al desarrollo de la qu\u00edmica de los reactivos de yodo hipervalente en el campo de la s\u00edntesis heteroc\u00edclica. en este sentido, hemos planteado procedimientos sencillos y de car\u00e1cter general que han dado acceso a variedad de sistemas n-heteroc\u00edclicos de alta valor a\u00f1adido utilizando una misma aproximaci\u00f3n sint\u00e9tica. Esta aproximaci\u00f3n consiste b\u00e1sicamente en la oxidaci\u00f3n de amidas convenientemente sustituidas promovida por el reactivo de yodo hipervalente pifa, y la posterior reacci\u00f3n intramolecular de los intermedios n-acilnitr\u00e9nicos as\u00ed generados con diferentes nucle\u00f3filos. As\u00ed, hemos observado que la naturaleza del nucle\u00f3filo en cuesti\u00f3n condiciona la del producto final.     cuando el nucle\u00f3filo de la reacci\u00f3n es un anillo (hetero)arom\u00e1tico tiene lugar un proceso de amidaci\u00f3n electr\u00f3fila arom\u00e1tica que ha permitido acceder a variedad de derivados 1,4-diazep\u00ednicos. Adem\u00e1s, dicha estrategia se ha aplicado satisfactoriamente a la s\u00edntesis total del antibi\u00f3tico antitumoral (+)-dc-81. cuando restos olef\u00ednicos act\u00faan como nucle\u00f3filos en dichas heterociclaciones tiene lugar un proceso de amidohidroxilaci\u00f3n que nos ha permitido sintetizar variedad de derivados indol\u00ednicos. por \u00faltimo, se ha puesto a punto un nuevo proceso de formaci\u00f3n de enlaces n-n y n-s en el que los intermedios nitr\u00e9nicos generados por el reactivo pifa son captados intramolecularmente por restos am\u00ednicos y ti\u00f3licos. Esta nueva transformaci\u00f3n se ha aplicado con \u00e9xito a la s\u00edntesis de derivados indazol\u00f3nicos, priazol\u00f3nicos y benzisotiazol\u00f3nicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de heterociclos nitrogenados por formaci\u00f3n de enlaces c-n, n-n y n-s a trav\u00e9s de procesos promovidos por el reactivo de yodo hipervalente pifa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de heterociclos nitrogenados por formaci\u00f3n de enlaces c-n, n-n y n-s a trav\u00e9s de procesos promovidos por el reactivo de yodo hipervalente pifa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Arkaitz Correa Navarro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Esther Dominguez Perez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carmen N\u00e1jera domingo <\/li>\n<li>jordi Marquet cortes (vocal)<\/li>\n<li> Granja guill\u00e1n  Juan  ram\u00f3n (vocal)<\/li>\n<li>Jes\u00fas Jim\u00e9nez-barbero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Arkaitz Correa Navarro El presente trabajo de tesis doctoral ha pretendido contribuir al desarrollo de la qu\u00edmica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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