{"id":55341,"date":"2006-03-11T00:00:00","date_gmt":"2006-03-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/importancia-del-gtp-en-la-iniciacion-y-reiniciacion-traduccional-eucarioticas\/"},"modified":"2006-03-11T00:00:00","modified_gmt":"2006-03-11T00:00:00","slug":"importancia-del-gtp-en-la-iniciacion-y-reiniciacion-traduccional-eucarioticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/importancia-del-gtp-en-la-iniciacion-y-reiniciacion-traduccional-eucarioticas\/","title":{"rendered":"Importancia del gtp en la iniciaci\u00f3n y reiniciaci\u00f3n traduccional eucari\u00f3ticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Diego Iglesias Gato <\/strong><\/h2>\n<p>En este trabajo hemos identificado gcd18 (gua1) como un nuevo represor traduccional de gcn4 en saccharomyces cerevisiae. Gcn4 es un factor de transcripci\u00f3n que regula la expresi\u00f3n de ~1\/10 de los genes de esta levadura en condiciones de escasez de amino\u00e1cidos siendo el elemento central del control general de la bios\u00edntesis de amino\u00e1cidos (gaac). gua1 es una gmp-sintetasa de la ruta de s\u00edntesis de novo del gtp en s. Cerevisiae. Hemos identificado la mutaci\u00f3n espont\u00e1nea gcd18-1 (gua1-g388d) que confiere fenotipo gcd (desrepresi\u00f3n del gaac), adem\u00e1s de crecimiento lento y termosensibilidad a 37\u00c2\u00b0c. Es la primera mutaci\u00f3n gcd que afecta a un gen de la ruta de bios\u00edntesis de nucle\u00f3tidos de guanina. el inicio de la traducci\u00f3n eucari\u00f3tica consiste en situar el trna iniciador cargado con el amino\u00e1cido metionina en un apareado con el codon de inicio apropiado de un rna mensajero. Este trna es transportado en un complejo ternario (tc) eif2\u00c2\u00bftrna\u00c2\u00bfgtp que antes de unirse a la part\u00edcula ribos\u00f3mica 40s se asocia a otros factores de iniciaci\u00f3n como eif1, 3 y 5 dando lugar al complejo multifactorial (mfc). Los mutantes gua1-g388d, que muestran reducidos niveles de  gtp, exhiben defectos en inicio de la traducci\u00f3n y mediante ensayos de co-inmunoprecipitaci\u00f3n hemos detectado que acumulan complejos de preiniciaci\u00f3n que constan de los componentes habituales (factores de iniciaci\u00f3n 1, 2, 3 y 5) y de trna iniciador. Esta acumulaci\u00f3n sin embargo, no sucede a nivel de la part\u00edcula ribos\u00f3mica 40s, sugiriendo que los complejos detectados carecen de gtp lo que les impide asociarse a 40s, apoyando la hip\u00f3tesis de que los componentes de dichos complejos podr\u00eda asociarse entre s\u00ed sin seguir un orden jer\u00e1rquico estricto. \tlos efectos de la limitaci\u00f3n de gtp sobre otros procesos celulares esenciales se podr\u00eda estudiar en levaduras utilizando la mutaci\u00f3n gua1-g388d, sin tener que recurrir a drogas que inhiben la bios\u00edntesis de nucle\u00f3tidos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Importancia del gtp en la iniciaci\u00f3n y reiniciaci\u00f3n traduccional eucari\u00f3ticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Importancia del gtp en la iniciaci\u00f3n y reiniciaci\u00f3n traduccional eucari\u00f3ticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Diego Iglesias Gato <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mercedes Gallardo Ortega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: amelia Nieto martin <\/li>\n<li>Jes\u00fas De la cruz diaz (vocal)<\/li>\n<li>Carlos Rodr\u00edguez v\u00e1zquez de aldana (vocal)<\/li>\n<li>Francisco Navarro gomez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diego Iglesias Gato En este trabajo hemos identificado gcd18 (gua1) como un nuevo represor traduccional de gcn4 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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