{"id":55381,"date":"2006-07-11T00:00:00","date_gmt":"2006-07-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/adicion-conjugada-estereocontrolada-desde-el-uso-de-auxiliares-quirales-hasta-la-organocatalisis-asimetrica-asymmetric-conjugate-addition-form-chiral-auxiliaries-to-organocatalysis\/"},"modified":"2006-07-11T00:00:00","modified_gmt":"2006-07-11T00:00:00","slug":"adicion-conjugada-estereocontrolada-desde-el-uso-de-auxiliares-quirales-hasta-la-organocatalisis-asimetrica-asymmetric-conjugate-addition-form-chiral-auxiliaries-to-organocatalysis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-heterociclicos\/adicion-conjugada-estereocontrolada-desde-el-uso-de-auxiliares-quirales-hasta-la-organocatalisis-asimetrica-asymmetric-conjugate-addition-form-chiral-auxiliaries-to-organocatalysis\/","title":{"rendered":"Adici\u00f3n conjugada estereocontrolada. desde el uso de auxiliares quirales hasta la organocat\u00e1lisis asim\u00e9trica (asymmetric conjugate addition form chiral auxiliaries to organocatalysis)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Efraim Reyes Mart\u00edn <\/strong><\/h2>\n<p>En el trabajo de investigaci\u00f3n que se presentar\u00e1 se ha realizado un estudio pormenorizado de la estereoselectividad de la reacci\u00f3n de adici\u00f3n conjugada y de la reacci\u00f3n de adici\u00f3n conjugada\/alfa-alquilaci\u00f3n, sobre lamidas alfa,beta-insaturadas derivadas del aminoalcohol seudoefedrina, con el objetivo de desarrollar una nueva metodolog\u00eda para el acceso de \u00e1cidos y alcoholes alquil-ramificados. As\u00ed, se ha comprobado que dicho auxiliar aminoalcoh\u00f3lico, (s,s)-(+)-seudoefedrina, ejerce una buena inducci\u00f3n 1,5 en la adici\u00f3n conjugada de reactivos organol\u00edticos y que adem\u00e1s, el intermedio de tipo enolato puede ser convenientemente atrapado, bien por un prot\u00f3n (adici\u00f3n conjugada) o bien por un electr\u00f3filo externo de tipo haluro de alquilo (adici\u00f3n conjugada\/alfa-alquilaci\u00f3n), observ\u00e1ndose en ambos casos altas estereoselectividades. Con las condiciones de reacci\u00f3n optimizadas se ha puesto a punto la s\u00edntesis de una gran variedad de amidas beta-alquil y alfa-beta-dialquilsustituidas las cuales se han transformado en productos de inter\u00e9s como son \u00e1cidos carbox\u00edlicos y alcoholes primarios, as\u00ed como de un producto natural.     asimismo, se ha desarrollado una metodolog\u00eda eficaz y sencilla para la obtenci\u00f3n de aductos de tipo michael llevando a cabo la reacci\u00f3n en condiciones aminocatal\u00edticas y empleando el aminoalcohol l-prolinol. En este caso, se ha optimizado la reacci\u00f3n de tipo michael entre aldeh\u00eddos y un nitroalqueno funcionalizado, lo que ha permitido la obtenci\u00f3n de productos de elevado inter\u00e9s.     por \u00faltimo, se ha estudiado el mecanismo de la reacci\u00f3n ald\u00f3lcia oragnocatal\u00edtica en la s\u00edntesis de derivados de az\u00facares y polic\u00e9tidos observ\u00e1ndose un proceso de tipo dykat catalizado por l-prolina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Adici\u00f3n conjugada estereocontrolada. desde el uso de auxiliares quirales hasta la organocat\u00e1lisis asim\u00e9trica (asymmetric conjugate addition form chiral auxiliaries to organocatalysis)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Adici\u00f3n conjugada estereocontrolada. desde el uso de auxiliares quirales hasta la organocat\u00e1lisis asim\u00e9trica (asymmetric conjugate addition form chiral auxiliaries to organocatalysis) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Efraim Reyes Mart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Badia Urrestarazu M. Dolores<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Mendoza sanz Javierde <\/li>\n<li>sergio Castilon miranda (vocal)<\/li>\n<li>rosa Mar\u00eda Claramunt vallesp\u00ed (vocal)<\/li>\n<li>erik Adolfsson hans (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Efraim Reyes Mart\u00edn En el trabajo de investigaci\u00f3n que se presentar\u00e1 se ha realizado un estudio pormenorizado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1412,6775,12909,30209],"tags":[95612,122359,122361,46794,3283,122360],"class_list":["post-55381","post","type-post","status-publish","format-standard","hentry","category-compuestos-heterociclicos","category-organometalicos","category-pais-vasco-euskal-herriko-unibertsitatea","category-quimica-de-carboaniones","tag-badia-urrestarazu-m-dolores","tag-efraim-reyes-martin","tag-erik-adolfsson-hans","tag-mendoza-sanz-javierde","tag-rosa-maria-claramunt-vallespi","tag-sergio-castilon-miranda"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55381","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=55381"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55381\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=55381"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=55381"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=55381"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}