{"id":55387,"date":"2006-07-11T00:00:00","date_gmt":"2006-07-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-del-polimorfismo-sst-1-del-gen-de-la-apoliprotea%c2%adna-c-iii-sobre-el-metabolismo-lipoproteico-en-pacientes-hipertensos-esenciales\/"},"modified":"2006-07-11T00:00:00","modified_gmt":"2006-07-11T00:00:00","slug":"influencia-del-polimorfismo-sst-1-del-gen-de-la-apoliprotea%c2%adna-c-iii-sobre-el-metabolismo-lipoproteico-en-pacientes-hipertensos-esenciales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-del-polimorfismo-sst-1-del-gen-de-la-apoliprotea%c2%adna-c-iii-sobre-el-metabolismo-lipoproteico-en-pacientes-hipertensos-esenciales\/","title":{"rendered":"Influencia del polimorfismo sst-1 del gen de la apoliprote\u00edna c-iii sobre el metabolismo lipoprot\u00e9ico en pacientes hipertensos esenciales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Barrios Artillo <\/strong><\/h2>\n<p>La hipertensi\u00f3n arterial es uno de los principales factores de riesgo cardiovascular y, frecuentemente, se asocia a dislipemias (aumento de los niveles plasm\u00e1ticos de colesterol total y triglic\u00e9ridos, y disminuci\u00f3n del colesterol-hdl) y un mayor grado de resistencia insul\u00ednica. La asociaci\u00f3n entre estos factores potencia exponencialmente sus efectos ateroescler\u00f3ticos.  existe un componente gen\u00e9tico en la patog\u00e9nesis de la aterosclerosis. Entre los genes implicados en el desarrollo de la aterosclerosis se encuentran los genes relacionados con el matabolismo lip\u00eddico y, entre estos, aquellos que codifican a las distintas apolipoprote\u00ednas.  la apolipoprote\u00edna c-iii es un componente fundamental de las vldl y las hgl, que juega un importante papel en el metabolismo de las lipoprote\u00ednas ricas en triglic\u00e9ridos. Existe un polimorfismo en el gen de la apo c-iii detectado por la endonucleasa de restricci\u00f3n sst-i, debido a una transici\u00f3n de citosina por guanina (c3238g), que da lugar a dos alelos: s1 y s2. La mayor\u00eda de los estudios publicados relacionan el alelo raro s2 con hipertrigliceridemia y un mayor riesgo de enfermedad coronaria en adultos y ni\u00f1os sanos, pacientes diab\u00e9ticos tipo 1 y 2, enfermos de cardiopat\u00eda isqu\u00e9mica y dislip\u00e9micos. Pero no se ha estudiado previamente los efectos de este polimorfismo en pacientes hipertensos esenciales. Los objetivos de este trabajo fueron: calcular la frecuencia del alelo s2 en pacientes hipertensos esenciales; determinar los niveles plasm\u00e1ticos de l\u00edpidos en estos pacientes seg\u00fan el genotipo sst-i y el perfil aterog\u00e9nico correspondiente, as\u00ed como su influencia sobre el metabolismo hidrocarbonado; y, por \u00faltimo, analizar el comportamiento de esta mutaci\u00f3n gen\u00e9tica en funci\u00f3n del sexo.  se realiz\u00f3 un estudio descriptivo transversal sobre 104 pacientes hipertensos esenciales (59 hombres y 45 mujeres), de reciente diagn\u00f3stico y sin tratamiento hipotensor o hipolipemiante, no diab\u00e9ticos y con el<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia del polimorfismo sst-1 del gen de la apoliprote\u00edna c-iii sobre el metabolismo lipoprot\u00e9ico en pacientes hipertensos esenciales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia del polimorfismo sst-1 del gen de la apoliprote\u00edna c-iii sobre el metabolismo lipoprot\u00e9ico en pacientes hipertensos esenciales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Barrios Artillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Espino Montoro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Blas Gil Extremera <\/li>\n<li> L\u00f3pez Chozas Jos\u00e9 Manuel (vocal)<\/li>\n<li>Pedro Mata Lopez (vocal)<\/li>\n<li>Andr\u00e9s Jim\u00e9nez Mar\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Barrios Artillo La hipertensi\u00f3n arterial es uno de los principales factores de riesgo cardiovascular y, frecuentemente, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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