{"id":55451,"date":"2018-03-09T22:43:08","date_gmt":"2018-03-09T22:43:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/penfigo-estudio-cla%c2%adnico-serologico-en-26-pacientes\/"},"modified":"2018-03-09T22:43:08","modified_gmt":"2018-03-09T22:43:08","slug":"penfigo-estudio-cla%c2%adnico-serologico-en-26-pacientes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/penfigo-estudio-cla%c2%adnico-serologico-en-26-pacientes\/","title":{"rendered":"Penfigo: estudio cl\u00ednico-serol\u00f3gico en 26 pacientes"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ricardo Suarez Fern\u00e1ndez <\/strong><\/h2>\n<p>Denominamos \u00abp\u00e9nfigo\u00bb a un grupo de enfermedades autoinmunes caracterizadas por acant\u00f3lisis histol\u00f3gica y formaci\u00f3n de ampollas. Existen varios tipos de p\u00e9nfigo pero b\u00e1sicamente se dividen en p\u00e9nfigo vulgar, p\u00e9nfigo foli\u00e1ceo y p\u00e9nfigo paranenopl\u00e1sico.     en la actualidad, para diagnosticar estas enfermedades, es necesaria una cl\u00ednica con ampollas y erosiones, histopatolog\u00eda con acant\u00f3lisis y detecci\u00f3n de anticuerpos en piel afecta (inmunofluorescencia directa) o en sangre circulante (inmunoflurescencia indirecta).     en los \u00faltimos a\u00f1os, existe una t\u00e9cnica de enzimunoan\u00e1lisis (elisa) que tambi\u00e9n detecta anticuerpos circulantes contra los ant\u00edgenos implicados: las desmogleinas.  objetivos     los objetivos de la presente tesis son comparar la sensibilidad y especificidad de estas dos \u00faltimas y demostrar si existe relaci\u00f3n de los niveles de elisa frente a desmogle\u00ednas con el grado de afectaci\u00f3n cut\u00e1neo-mucoso.  material y m\u00e9todos     se obtuvieron 117 determinaciones en 26 pacientes con p\u00e9nfigo y 29 determinaciones en pacientes con otras enfermedades ampulosas como grupo control. Medimos anticuerpos antisustancia intercelular por inmunofluorescencia indirecta y anticuerpos antidesmogle\u00edna 1 y 3 por elisa. Tambi\u00e9n se midieron las cifras de anticuperos antes y despu\u00e9s de terpias como las inmunoglobulinas intravenosas y plasmaf\u00e9resis.  resultados     la determinaci\u00f3n de anticuerpos por elisa frente a desmogle\u00ednas 1 y 3 es m\u00e1s sensible que la inmunofluorescencia indirecta. No encontramos diferencias en cuanto a especificidad. Los niveles de anticuerpos son paralelos a la actividad cl\u00ednica. Estos niveles no descienden inmediatamente tras la terpia con inmunoglobulinas intravenosas.  palabras clave     penfigo, demsogle\u00ednas, ampollas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Penfigo: estudio cl\u00ednico-serol\u00f3gico en 26 pacientes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Penfigo: estudio cl\u00ednico-serol\u00f3gico en 26 pacientes <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ricardo Suarez Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pablo Lazaro Ochaita<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: aurora Fuerra tapia <\/li>\n<li>pedro Ja\u00e9n olasolo (vocal)<\/li>\n<li>angel Simon mercan (vocal)<\/li>\n<li>Mar\u00eda no Casado jimenez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ricardo Suarez Fern\u00e1ndez Denominamos \u00abp\u00e9nfigo\u00bb a un grupo de enfermedades autoinmunes caracterizadas por acant\u00f3lisis histol\u00f3gica y formaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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