{"id":55505,"date":"2018-03-09T22:43:12","date_gmt":"2018-03-09T22:43:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/potencial-endotelial-arterial-y-venoso-de-las-celulas-madre-adultas\/"},"modified":"2018-03-09T22:43:12","modified_gmt":"2018-03-09T22:43:12","slug":"potencial-endotelial-arterial-y-venoso-de-las-celulas-madre-adultas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/embriologia\/potencial-endotelial-arterial-y-venoso-de-las-celulas-madre-adultas\/","title":{"rendered":"Potencial endotelial arterial y venoso de las celulas madre adultas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Xabier Lopez Aranguren <\/strong><\/h2>\n<p>Many stem celi types have been shown to differentiate into endothelial cells (ecs), however, their specification to arterial or venous endothelium remains unexplored. We tested whether a specific arterial or venous ec fate could be induced in human multipotent adult progenitor cells (hmapcs) and ac133+ cells (hacl33+). In vitro, in the presence of vegf165, hacl33+ cells only adopted a venous and microvascular ec phenotype, while hmapcs differentiated into both arterial and venous ecs, possibly because hmapcs expressed significantly more sonic hedgehog (shh) and its receptors, as well as noten 1 and 3 receptors and some of their ligands. Accordingly, blocking either of those pathways attenuated in vitro arterial ec differentiation from hmapcs. Complementarily, stimulating these pathways by addition of delta-like 4 (dll-4), a notch ligand, and shh to vegf165 further boosted arterial differentiation in hmapcs both in vitro and in an in vivo matrigel model. These results represent the first demonstration of adult stem celis with the potential to be differentiated into different types of ecs in vitro and in vivo and provide a useful human model to study arterio-venous specification.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Potencial endotelial arterial y venoso de las celulas madre adultas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Potencial endotelial arterial y venoso de las celulas madre adultas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Xabier Lopez Aranguren <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Felipe Luis Prosper Cardoso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas m. Prieto valtue\u00f1a <\/li>\n<li>Jos\u00e9 Carlos Segovia sanz (vocal)<\/li>\n<li>\u00e1lvaro Urbano ispiz\u00faa (vocal)<\/li>\n<li>Mar\u00eda  consuelo Juan a Del ca\u00f1izo fernandez roldan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Xabier Lopez Aranguren Many stem celi types have been shown to differentiate into endothelial cells (ecs), however, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9399,350,17749],"tags":[38197,18255,15059,84394,9401,122634],"class_list":["post-55505","post","type-post","status-publish","format-standard","hentry","category-cultivo-celular","category-embriologia","category-navarra","tag-alvaro-urbano-ispizua","tag-felipe-luis-prosper-cardoso","tag-jesus-m-prieto-valtuena","tag-jose-carlos-segovia-sanz","tag-maria-consuelo-juan-a-del-canizo-fernandez-roldan","tag-xabier-lopez-aranguren"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55505","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=55505"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55505\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=55505"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=55505"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=55505"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}