{"id":55506,"date":"2018-03-09T22:43:12","date_gmt":"2018-03-09T22:43:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacoepidemiologa%c2%ada-y-farmacogenetica-de-la-esquizofrenia\/"},"modified":"2018-03-09T22:43:12","modified_gmt":"2018-03-09T22:43:12","slug":"farmacoepidemiologa%c2%ada-y-farmacogenetica-de-la-esquizofrenia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacos-psicotropicos\/farmacoepidemiologa%c2%ada-y-farmacogenetica-de-la-esquizofrenia\/","title":{"rendered":"Farmacoepidemiolog\u00eda y farmacogen\u00e9tica de la esquizofrenia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Macarena C\u00e1ceres Le\u00f3n <\/strong><\/h2>\n<p>La introducci\u00f3n de antipsic\u00f3ticos de nueva generaci\u00f3n (at\u00edpicos) para el tratamiento de la esquizofrenia parece presentar como ventaja frente a los cl\u00e1sicos (t\u00edpicos) una mayor eficacia y un menor n\u00famero de efectos adversos, sin embargo su coste es muy superior.     otra pol\u00e9mica es la prescripci\u00f3n de antipsic\u00f3ticos en mono o politerapia, lo que podr\u00eda ser relevante por las potenciales interacciones farmacol\u00f3gicas causante de efectos adversos y de posibles hospitalizaciones de estos enfermos.     uno de los problemas relacionados con el tratamiento de la esquizofrenia es la existencia de una gran variabilidad en la respuesta a los f\u00e1rmacos antipsic\u00f3ticos. \u00e9sta puede explicarse por la variaci\u00f3n interindividual en su metabolismo debido a la implicaci\u00f3n de enzimas (citocromo 450) con polim\u00f3rfismo gen\u00e9tico, lo que se ha demostrado en estudios farmacocin\u00e9ticos. Entre ellas, el cyp2d6 parece el citocromo m\u00e1s relevante en el metabolismo de f\u00e1rmacos antipsic\u00f3ticos, base del tratamiento de la esquizofrenia.     el objetivo general fue analizar la relevancia de factores relacionados con la prescripci\u00f3n(antipsic\u00f3ticos t\u00edpicos frente a at\u00edpicos, monoterapia frente a politerapia), as\u00ed como factores farmacogen\u00e9ticos (genotipos cyp2d6) en el numero de ingresos y la estancias hospitalarias de los pacientes esquizofr\u00e9nicos.     el uso total de antipsic\u00f3ticos con atenci\u00f3n primaria en extremadura ha aumentado considerablemente a lo largo del periodo de estudio. Los antipsic\u00f3ticos m\u00e1s utilizados en atenci\u00f3n primaria fueron haloperidol y risperidona. En los \u00faltimos a\u00f1os el uso de antipsic\u00f3ticos at\u00edpicos ha aumentado grandemente. Se pudo estimar que m\u00e1s del 80% de las prescripciones lo fueron con sustratos del cyp2d6.     se ha observado una relaci\u00f3n entre el aumento del uso de antipsic\u00f3ticos at\u00edpicos en atenci\u00f3n primaria y la disminuci\u00f3n del n\u00famero de ingresos hospitalarios de pacientes esquizofr\u00e9nicos en extremadura.     los re<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacoepidemiolog\u00eda y farmacogen\u00e9tica de la esquizofrenia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacoepidemiolog\u00eda y farmacogen\u00e9tica de la esquizofrenia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Macarena C\u00e1ceres Le\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Adrian Llerena Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: m\u00e1ximo Bartolom\u00e9 rodr\u00edguez <\/li>\n<li> Rubia mart\u00ednez Alberto de la (vocal)<\/li>\n<li>Jos\u00e9 Antonio Abadin delgado (vocal)<\/li>\n<li> Sampaio rodrigues queiroz joao Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Macarena C\u00e1ceres Le\u00f3n La introducci\u00f3n de antipsic\u00f3ticos de nueva generaci\u00f3n (at\u00edpicos) para el tratamiento de la esquizofrenia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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