{"id":55508,"date":"2018-03-09T22:43:12","date_gmt":"2018-03-09T22:43:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacogenetica-del-cyp2d6-en-una-poblacion-cubana\/"},"modified":"2018-03-09T22:43:12","modified_gmt":"2018-03-09T22:43:12","slug":"farmacogenetica-del-cyp2d6-en-una-poblacion-cubana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacos-psicotropicos\/farmacogenetica-del-cyp2d6-en-una-poblacion-cubana\/","title":{"rendered":"Farmacogen\u00e9tica del cyp2d6 en una poblaci\u00f3n cubana"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Idilio Gonz\u00e1lez Mart\u00ednez <\/strong><\/h2>\n<p>En la pr\u00e1ctica cl\u00ednica se observa frecuentemente que la respuesta al tratamiento farmacol\u00f3gico var\u00eda ampliamente entre pacientes tratados con la misma dosis, existiendo diferencias tanto en la eficacia como en la presencia de efectos adversos. Factores gen\u00e9ticos y ambientales pueden modificar la actividad de las enzimas metabolizadoras de f\u00e1rmacos, y por tanto ser causante de diferencias en la concentraci\u00f3n plasm\u00e1tica, que a su vez pueden ser determinantes de la variabilidad interindividual e inter\u00e9tnica en la respuesta terap\u00e9utica y en la presentaci\u00f3n de efectos secundarios. Uno los mayores determinantes de esta variabilidad es el polimorfismo gen\u00e9tico del sistema enzim\u00e1tico del citocromo p450 (cyp) de entre ellos el m\u00e1s estudiado es el cyp2d6, analizado en esta tesis.     las diferencias en las frecuencias en que se presentan las distintas variantes al\u00e9licas del gen cyp2d6 en diferentes poblaciones, podr\u00eda justificar la variabilidad inter\u00e9tnica observada en la respuesta a los f\u00e1rmacos. El estudio de la variabilidad inter\u00e9tnica en la actividad y genotipos cyp2d6 en la poblaci\u00f3n cubana es el objetivo principal de esta tesis doctoral. Esta se justifica por la existencia de pocos estudios en poblaciones latinoamericanas. El conocimiento de la variabilidad poblacional podr\u00eda ser de gran utilidad para la optimizaci\u00f3n y adaptaci\u00f3n de las pautas terap\u00e9uticas a cada poblaci\u00f3n.     los resultados principales de este trabajo demuestran la existencia del polimorfismo gen\u00e9tico cyp2d6 en la poblaci\u00f3n de voluntarios sanos cubana, con una frecuencia de un 4,6 de mls y un 3,8% de urs. Adem\u00e1s se demostr\u00f3 diferencias en la capacidad metab\u00f3lica cyp2d6 entre cubanos clasificados como blancos y mestizos, probablemente debida a la distinta frecuencia del alelo cyp2d6*17 entre ambos grupos, as\u00ed como una relaci\u00f3n entre la capacidad de hidroxilaci\u00f3n de debrisoquina y ciertas caracter\u00edsticas de la personalidad, lo que ha hecho que los mls son m\u00e1s prop<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacogen\u00e9tica del cyp2d6 en una poblaci\u00f3n cubana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacogen\u00e9tica del cyp2d6 en una poblaci\u00f3n cubana <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Idilio Gonz\u00e1lez Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Adrian Llerena Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: m\u00e1ximo Bartolom\u00e9 rodr\u00edguez <\/li>\n<li>Jos\u00e9 Antonio Dur\u00e1n quintana (vocal)<\/li>\n<li>Jes\u00fas Cobaleda polo (vocal)<\/li>\n<li> Ribeiro marques vera linda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Idilio Gonz\u00e1lez Mart\u00ednez En la pr\u00e1ctica cl\u00ednica se observa frecuentemente que la respuesta al tratamiento farmacol\u00f3gico var\u00eda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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