{"id":55520,"date":"2018-03-09T22:43:12","date_gmt":"2018-03-09T22:43:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-funcion-de-la-quimioquina-cxcl12-heterodimerizacion-de-su-receptor-cxcr4-con-el-receptor-opiaceo-y-activacion-de-la-ruta-jak-stat\/"},"modified":"2018-03-09T22:43:12","modified_gmt":"2018-03-09T22:43:12","slug":"regulacion-de-la-funcion-de-la-quimioquina-cxcl12-heterodimerizacion-de-su-receptor-cxcr4-con-el-receptor-opiaceo-y-activacion-de-la-ruta-jak-stat","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/regulacion-de-la-funcion-de-la-quimioquina-cxcl12-heterodimerizacion-de-su-receptor-cxcr4-con-el-receptor-opiaceo-y-activacion-de-la-ruta-jak-stat\/","title":{"rendered":"Regulaci\u00f3n de la funci\u00f3n de la quimioquina cxcl12: heterodimerizaci\u00f3n de su receptor, cxcr4, con el receptor opi\u00e1ceo y activaci\u00f3n de la ruta jak\/stat"},"content":{"rendered":"<h2>Tesis doctoral de <strong> \u00f3scar Mu\u00f1iz Pello <\/strong><\/h2>\n<p>El trabajo experimental realizado versa sobre la regulaci\u00f3n de la se\u00f1alizaci\u00f3n de la quimioquina cxcl12 a trav\u00e9s de su receptor cxcr4.     las quimioquinas son peque\u00f1as mol\u00e9culas proinflamatorias, claves en el posicionamiento de las c\u00e9lulas del sistema inmune en tiempo y lugar adecuados. De hecho, se profundiza en el hecho de que los receptores de quimioquinas, miembros de la familia de gpcr forman heterod\u00edmeros con otros receptores de la misma familia, y en concreto, en esta tesis se describe como el receptor de quimioquinas cxcr4 es capaz de heterodimerizar con el receptor opi\u00e1ceo en c\u00e9lulas del sistema inmunol\u00f3gico, lo que resulta en un nuevo receptor que es incapaz de se\u00f1alizar en presencia de los correspondientes ligandos a\u00f1adidos simult\u00e1neamente. Este resultado permite bloquear la respuesta celular a cxcl12, as\u00ed como bloquear las funciones cxcr4 y de los receptores de opioides.     adem\u00e1s, durante el desarrollo de esta primera parte, se observ\u00f3 que los opioides eran capaces de inducir la adhesi\u00f3n de monocitos a fibronectina y se procedi\u00f3 a caracterizar la ruta de se\u00f1alizaci\u00f3n correspondiente, y a que el efecto de los opioides, actuando directamente como reguladores de la respuesta inmunol\u00f3gica, es todav\u00eda bastante desconocida.     por otro lado el trabajo define la importancia fisiol\u00f3gica que tiene la activaci\u00f3n de la ruta jak\/stat por quimioquinas y demuestra como la expresi\u00f3n de supresores de la se\u00f1alizaci\u00f3n por citoquina s(socs) bloquea la se\u00f1alizaci\u00f3n del par cxcl12\/cxcr4, implicado  en la retenci\u00f3n de c\u00e9lulas madre hematopoy\u00e9ticas de la m\u00e9dula \u00f3sea, provocando la r\u00e1pida movilizaci\u00f3n de esta poblaci\u00f3n celular a la circulaci\u00f3n perif\u00e9rica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la funci\u00f3n de la quimioquina cxcl12: heterodimerizaci\u00f3n de su receptor, cxcr4, con el receptor opi\u00e1ceo y activaci\u00f3n de la ruta jak\/stat<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la funci\u00f3n de la quimioquina cxcl12: heterodimerizaci\u00f3n de su receptor, cxcr4, con el receptor opi\u00e1ceo y activaci\u00f3n de la ruta jak\/stat <\/li>\n<li><strong>Autor:<\/strong>\u00a0 \u00f3scar Mu\u00f1iz Pello <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Mellado Garc\u00eda Jos\u00e9 Mario<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: margarita Fern\u00e1ndez Garc\u00eda de castro <\/li>\n<li>Juan  Antonio Bueren roncero (vocal)<\/li>\n<li>balbino Jos\u00e9 Alarcon sanchez (vocal)<\/li>\n<li>Francisco Sanchez Madrid (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de \u00f3scar Mu\u00f1iz Pello El trabajo experimental realizado versa sobre la regulaci\u00f3n de la se\u00f1alizaci\u00f3n de la quimioquina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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