{"id":55582,"date":"2018-03-09T22:43:15","date_gmt":"2018-03-09T22:43:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-de-biocompatibilidad-de-pola%c2%admeros-de-poli-epsilon-caprolactona-hacia-el-desarrollo-de-un-implante-vascular-biodegradable\/"},"modified":"2018-03-09T22:43:15","modified_gmt":"2018-03-09T22:43:15","slug":"estudios-de-biocompatibilidad-de-pola%c2%admeros-de-poli-epsilon-caprolactona-hacia-el-desarrollo-de-un-implante-vascular-biodegradable","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/estudios-de-biocompatibilidad-de-pola%c2%admeros-de-poli-epsilon-caprolactona-hacia-el-desarrollo-de-un-implante-vascular-biodegradable\/","title":{"rendered":"Estudios de biocompatibilidad de pol\u00edmeros de poli-(epsilon-caprolactona). hacia el desarrollo de un implante vascular biodegradable"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Serrano L\u00f3pez-terradas M\u00aa Concepci\u00f3n <\/strong><\/h2>\n<p>La creciente preValencia de las patolog\u00edas cardiovasculares en los pa\u00edses industrializados ha incrementado la necesidad cl\u00ednica de sustitutos apropiados que reemplacen el tejido vascular da\u00f1ado. La ingenier\u00eda de tejidos incorpora los principios de la ingenier\u00eda y la qu\u00edmica de pol\u00edmeros a las ciencias de la vida con el prop\u00f3sito de desarrollar sustitutos biol\u00f3gicos de tejidos y \u00f3rganos da\u00f1ados (niklason y langer, 1997). Esta \u00e1rea multidisciplinar de reciente desarrollo se ha convertido en los \u00faltimos a\u00f1os en una disciplina de futuro prometedor capaz de desarrollar sistemas que pueden ser utilizados para reemplazar vasos sangu\u00edneos da\u00f1ados o alterados (ratcliffe, 2000).  el objetivo general planteado en la presente tesis doctoral ha sido el estudio de la biocompatibilidad de pol\u00edmeros de poli-(epsilon-caprolactona) (pcl) como soporte para el futuro desarrollo, mediante el uso de t\u00e9cnicas de ingenier\u00eda de tejidos, de implantes biodegradables con potencial uso en cirug\u00eda cardiovascular.  los estudios iniciales se realizaron con la l\u00ednea establecida de fibroblastos murinos l929. A continuaci\u00f3n se procedi\u00f3 al aislamiento y caracterizaci\u00f3n de c\u00e9lulas endoteliales y c\u00e9lulas de m\u00fasculo liso a partir de biopsias de vena cava de cerdo, siendo posteriormente cultivadas sobre las l\u00e1minas del pol\u00edmero. Finalmente, y con el prop\u00f3sito de optimizar el proceso de endotelializaci\u00f3n del implante de pcl, se obtuvieron y caracterizaron c\u00e9lulas endoteliales a partir de c\u00e9lulas progenitoras perif\u00e9ricas de sangre de cerdo.  la metodolog\u00eda empleada para la realizaci\u00f3n de estos estudios se ha basado en las t\u00e9cnicas de cultivo celular y los ensayos bioqu\u00edmicos que se han considerado adecuados de acuerdo con los prop\u00f3sitos perseguidos. Entre los par\u00e1metros celulares evaluados cabe destacar: adhesi\u00f3n, proliferaci\u00f3n, morfolog\u00eda, tama\u00f1o y complejidad, actividad mitocondrial, ciclo celular, contenido en especies reactivas de ox\u00edgeno, potencial de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios de biocompatibilidad de pol\u00edmeros de poli-(epsilon-caprolactona). hacia el desarrollo de un implante vascular biodegradable<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios de biocompatibilidad de pol\u00edmeros de poli-(epsilon-caprolactona). hacia el desarrollo de un implante vascular biodegradable <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Serrano L\u00f3pez-terradas M\u00aa Concepci\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Portol\u00e9s P\u00e9rez M\u00aa Teresa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda Vallet Reg\u00ed <\/li>\n<li>Julia Bujan Varela (vocal)<\/li>\n<li> Comas Illas Juan  Valent\u00edn (vocal)<\/li>\n<li>Myriam Catal\u00e1 Rodr\u00edguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Serrano L\u00f3pez-terradas M\u00aa Concepci\u00f3n La creciente preValencia de las patolog\u00edas cardiovasculares en los pa\u00edses industrializados ha incrementado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,160],"tags":[122808,14278,2591,51818,122807,122806],"class_list":["post-55582","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-bioquimica","tag-comas-illas-juan-valentin","tag-julia-bujan-varela","tag-maria-vallet-regi","tag-myriam-catala-rodriguez","tag-portoles-perez-ma-teresa","tag-serrano-lopez-terradas-ma-concepcion"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55582","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=55582"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55582\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=55582"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=55582"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=55582"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}