{"id":55616,"date":"2018-03-09T22:43:19","date_gmt":"2018-03-09T22:43:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-sa%c2%adntesis-de-gmpc-en-celulas-miocardicas-efectos-de-la-isquemia-reperfusion\/"},"modified":"2018-03-09T22:43:19","modified_gmt":"2018-03-09T22:43:19","slug":"modulacion-de-la-sa%c2%adntesis-de-gmpc-en-celulas-miocardicas-efectos-de-la-isquemia-reperfusion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/modulacion-de-la-sa%c2%adntesis-de-gmpc-en-celulas-miocardicas-efectos-de-la-isquemia-reperfusion\/","title":{"rendered":"Modulaci\u00f3n de la s\u00edntesis de gmpc en c\u00e9lulas mioc\u00e1rdicas: efectos de la isquemia-reperfusi\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Noelia Escalona Aras <\/strong><\/h2>\n<p>El gmpc es un mensajero intracelular que act\u00faa como mediador de importantes acciones del \u00f3xido n\u00edtrico y del p\u00e9ptido natriur\u00e9tico atrial. Se ha descrito una reducci\u00f3n notable del contenido de gmpc en el miocardio de rata y de cerdo sometidos a una isquemia transitoria. Adem\u00e1s, se ha demostrado que el gmpc reduce el da\u00f1o mioc\u00e1rdico por reperfusi\u00f3n. En este trabajo se han investigado los mecanismos que modulan la concentraci\u00f3n de gmpc durante la isquemia y reperfusi\u00f3n mioc\u00e1rdicas en c\u00e9lulas endoteliales microvasculares coronarias y en caridomiocitos de rata adulta. En c\u00e9lulas endoteliales microvasculares, la isquemia simulada (hipoxia en condiciones \u00e1cidas) reduce dr\u00e1sticamente el contenido de gmpc basal y la capacidad de estas c\u00e9lulas para sintetizar gmpc en respuesta tanto a la estimulaci\u00f3n de la guanilil ciclasa sensible a no (gc-no) como de la guanilil ciclasa particulada (gcp). La acidosis y la depleci\u00f3n energ\u00e9tica participan en esta reducic\u00f3n. En cardiomiocitos de rata, la isquemia reduce la s\u00edntesis de gmoc dependiente de la actividad guanilil ciclasa particulada, pero no afecta de forma significativa la s\u00edntesis mediada por guanilil ciclasa dependiente de no. El efecto de la acidosis sobre la s\u00edntesis de gmpc parece ser un efecto directo sobre la actividad de los enzimas de s\u00edntesis (gc-no y gcp) dada la causada dependencia del ph que se observa cuando se determina la actividad in vitro. La reperfusi\u00f3n simulada revierte completamente los efectos de la acidosis previa en los dos tipos celulares, era s\u00f3lo parcialmente la reducci\u00f3n induc\u00eda por hipoxia.     el hecho de que en cardiomiocitos la s\u00edntesis de gmpc mediada por gc-no no se vea afectada por condiciones de acidosis intracelular, cuando el enzima es extremadamente sensible al ph in vitro, ha de pensar en una regulaci\u00f3n compleja del enzima durante la isquemia-reperfusi\u00f3n. En este sentido, se ha descrito recientemente que la actividad gc-no puede encontrarse asociada a la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de la s\u00edntesis de gmpc en c\u00e9lulas mioc\u00e1rdicas: efectos de la isquemia-reperfusi\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de la s\u00edntesis de gmpc en c\u00e9lulas mioc\u00e1rdicas: efectos de la isquemia-reperfusi\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Noelia Escalona Aras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>dorado Garc\u00eda Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jaume Bosch genover <\/li>\n<li>Juan Hidalgo (vocal)<\/li>\n<li>marisol Ruiz meana (vocal)<\/li>\n<li>joan Roseell\u00f3 catafau (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Noelia Escalona Aras El gmpc es un mensajero intracelular que act\u00faa como mediador de importantes acciones del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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