{"id":55628,"date":"2018-03-09T22:43:19","date_gmt":"2018-03-09T22:43:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/biosintesis-combinatoria-de-indolocarbazoles-para-la-obtencion-de-nuevos-derivados-antitumorales\/"},"modified":"2018-03-09T22:43:19","modified_gmt":"2018-03-09T22:43:19","slug":"biosintesis-combinatoria-de-indolocarbazoles-para-la-obtencion-de-nuevos-derivados-antitumorales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/biosintesis-combinatoria-de-indolocarbazoles-para-la-obtencion-de-nuevos-derivados-antitumorales\/","title":{"rendered":"Biosintesis combinatoria de indolocarbazoles para la obtenci\u00f3n de nuevos derivados antitumorales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Aaroa Perez Salas <\/strong><\/h2>\n<p>Los indolocarbazoles constituyen un grupo de productos naturales con caracter\u00edsticas estructurales originales e importantes aplicaciones terap\u00e9uticas. Actualmente se est\u00e1 llevando a cabo un gran esfuerzo en la generaci\u00f3n de nuevos derivados para el tratamiento de varias enfermedades, incluyendo el c\u00e1ncer y des\u00f3rdenes neurodegenerativos. El indolocarbazol estaurosporina es un potente inhibidor de una gran variedad de prote\u00ednas quinasas, contiene una mol\u00e9cula de az\u00facar unida a trav\u00e9s de dos enlaces c-n a ambos nitr\u00f3genos indoles del aglic\u00f3n indolocarbazol.  la bios\u00edntesis de estaurosporina fue reconstituida in vivo en un hu\u00e9sped heter\u00f3logo streptomyces albus usando dos pl\u00e1smidos diferentes: el pl\u00e1smido aglic\u00f3n que expresa un grupo de genes implicados en la bios\u00edntesis del n\u00facleo indolocarbazol junto con stag (codifica para una glicosiltransferasa) y\/\u00f3 stan (codifica par aun p450 oxigenasa), y el plasmido az\u00facar, que expresa un grupo de genes responsables de la mol\u00e9cula de az\u00facar. La uni\u00f3n del az\u00facar a los dos \u00e1tomos de nitr\u00f3geno del n\u00facleo indolocarbazol era dependiente de la acci\u00f3n combinada de stag y stan. Cuando stan estaba ausente, el az\u00facar se encontraba unido a s\u00f3lo uno delos dos \u00e1tomos de nitr\u00f3geno a trav\u00e9s de un enlace n-glicos\u00eddico, como en el indolocarbazol rebecamicina, la glicosiltransferasa stag mostr\u00f3 flexibilidad respecto al az\u00facar unido. Cuando el pl\u00e1smido az\u00facar era sustituido por pl\u00e1smido que dirigen la bios\u00edntesis de l-ramnosa, lidigitoxosa, l-olivosa, respectivamente, stag y stan eran capaces de transferir y unir todos estos az\u00facares aglic\u00f3n indolocarbazol. Como resultado de este trabajo se generaron varias cepas recombinantes que dieron lugar a nuevos derivados de la familia de los indolocarbazoles.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Biosintesis combinatoria de indolocarbazoles para la obtenci\u00f3n de nuevos derivados antitumorales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Biosintesis combinatoria de indolocarbazoles para la obtenci\u00f3n de nuevos derivados antitumorales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Aaroa Perez Salas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Salas Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  evaristo Suarez fernandez <\/li>\n<li>Francisco Malpartida romero (vocal)<\/li>\n<li>Francisco Garcia del portillo (vocal)<\/li>\n<li> Fernandez aparicio Jes\u00fas Manuel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aaroa Perez Salas Los indolocarbazoles constituyen un grupo de productos naturales con caracter\u00edsticas estructurales originales e importantes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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