{"id":55640,"date":"2018-03-09T22:43:19","date_gmt":"2018-03-09T22:43:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estructura-tridimensional-del-domini-extracel-lular-de-4f2hc-cd98-huma\/"},"modified":"2018-03-09T22:43:19","modified_gmt":"2018-03-09T22:43:19","slug":"estructura-tridimensional-del-domini-extracel-lular-de-4f2hc-cd98-huma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/estructura-tridimensional-del-domini-extracel-lular-de-4f2hc-cd98-huma\/","title":{"rendered":"Estructura tridimensional del domini extracel-lular de 4f2hc (cd98) hum\u00c1\u00a0"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Fort I Baixeras Joana <\/strong><\/h2>\n<p>La familia de transportadores heterom\u00e9ticos de amino\u00e1cidos (hats) posee la caracter\u00edstica \u00fanica de estar compuestos por dos subunidades; una subunidad pesada (hshat) y una subunidad ligera (lshat) unidas por un puente disulfuro. Mutaciones en alguno de sus miembros son responsables de aminoacidurias hereditarias, como la lisinuria con intolerancia a prote\u00ednas (lpi) o la cistinuria.     esta tesis recoge los resultados obtenidos a partir de la expresi\u00f3n en e.Coli y la posterior purificaci\u00f3n del dominio extracelular de 4f2hc humano, una de las cadenas pesadas de los transportadores heterom\u00e9ricos de amino\u00e1cidos. El principal resultado es la resoluci\u00f3n de la estructura tridimensional de este domino de la prote\u00edna mediante cristalizaci\u00f3n y difracci\u00f3n de rayos x.  se ha resuelto dos tipos de cristales, el monoclinico a 2,1 a (con una molecular en la unidad asim\u00e9trica) y el ortor\u00f3mbico a 2,8 a (con dos mol\u00e9culas en la unidad asim\u00e9trica coordinando un \u00e1tomo de zinc). El ectodominio de 4f2hc tiene una estructura muy parecida a las alfa-glucosidasas de insectos y consta de un dominio a, que es un barril (alfa\/beta)8 o barril tim y un dominio c, compuesto por 8 hojas beta antiparalelas. El trabajo presenta la estructura de 4f2hc y la compara con las estructuras conocidas de glucosidasas de bacterias. tambi\u00e9n se presenta un modelo estructural para rbat, la otra subunidad pesada de los transportadores heterom\u00e9ricos de amino\u00e1cidos. Pero la producci\u00f3n i purificaci\u00f3n de esta prote\u00edna nos ha permitido realizar, tambi\u00e9n, estudios de funci\u00f3n y interacci\u00f3n con otras mol\u00e9culas. Esta tesis intenta aportar informaci\u00f3n para el estudio estructura-funci\u00f3n de estos transportadores, pero tambi\u00e9n para el estudio de las diferentes funciones y procesos en los que 4f2hc hga estado vinculado en la liberatura, como funci\u00f3n de integrinas y tumorig\u00e9nesis. Finalmente se discute sobre la existencia fisiol\u00f3gica del homod\u00edmero del ectodominio encontrado en el cristal<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estructura tridimensional del domini extracel-lular de 4f2hc (cd98) hum\u00c1\u00a0<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estructura tridimensional del domini extracel-lular de 4f2hc (cd98) hum\u00c1\u00a0 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Fort I Baixeras Joana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Palac\u00edn Prieto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: modesto Orozco l\u00f3pez <\/li>\n<li> Carpena i vilella xavier (vocal)<\/li>\n<li> Casanovas suelves Jos\u00e9 m. (vocal)<\/li>\n<li>Antonio Planas sauter (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fort I Baixeras Joana La familia de transportadores heterom\u00e9ticos de amino\u00e1cidos (hats) posee la caracter\u00edstica \u00fanica de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,3178],"tags":[32768,122926,122927,122925,7153,15623],"class_list":["post-55640","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-proteinas","tag-antonio-planas-sauter","tag-carpena-i-vilella-xavier","tag-casanovas-suelves-jose-m","tag-fort-i-baixeras-joana","tag-manuel-palacin-prieto","tag-modesto-orozco-lopez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=55640"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55640\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=55640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=55640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=55640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}