{"id":55681,"date":"2018-03-09T22:43:23","date_gmt":"2018-03-09T22:43:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/oligonucleotide-based-biosensors-for-label-free-electrochemical-protein-and-dna-detection\/"},"modified":"2018-03-09T22:43:23","modified_gmt":"2018-03-09T22:43:23","slug":"oligonucleotide-based-biosensors-for-label-free-electrochemical-protein-and-dna-detection","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/analisis-electroquimico\/oligonucleotide-based-biosensors-for-label-free-electrochemical-protein-and-dna-detection\/","title":{"rendered":"Oligonucleotide based-biosensors for label-free electrochemical protein and dna detection"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00f3nica Mir Llorente <\/strong><\/h2>\n<p>El trabajo hecho en esta tesis describe el desarrollo de nuevas plataformas de biosensores electroqu\u00edmicos para conseguir sistemas que permitan una detecci\u00f3n sencilla del analito, por tanto que nos sea necesario un marcaje previo de este o bien tener que a\u00f1adir reactivos para su detecci\u00f3n.  Esta plataforma biosens\u00f3rica tambi\u00e9n ha de permitir la detecci\u00f3n de una amplia gama de analitos en el mismo equipo a un bajo coste. para evitar el marcaje de muestras de adn se desarrollo un sistema de desplazamiento.  Este m\u00e9todo libre de marcaje se basa en el desplazamiento de mol\u00e9culas de oligonucle\u00f3tido mutado y marcado, el cual aunque contenga mutaciones es capaz de hibridar con la sonda de reconocimiento inmovilizada en el biosensor, i por tanto cuando esta se encuentra en presencia del analito, debido a que la sonda tiene mayor afinidad por el analito que por la mol\u00e9cula mutada, el analito desplaza el oligonucle\u00f3tido mutado y marcado, diminuyendo as\u00ed la se\u00f1al del biosensor, la cual es proporcional a la concentraci\u00f3n del analito. tambi\u00e9n se llevaron a cabo diferentes estrategias para desarrollar un biosensor electroqu\u00edmico basado en oligonucle\u00f3tidos (apt\u00e1meros) para la detecci\u00f3n de prote\u00edna sin un previo marcaje de este analito.  Obteniendo as\u00ed un sistema gen\u00e9rico basado en oligonucle\u00f3tidos, que puede detectar tanto \u00e1cidos nucleicos como prote\u00ednas.  Se demostraron cinco configuraciones de biosensores electroqu\u00edmicos basados en apt\u00e1meros para la detecci\u00f3n de trombina no marcada.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Oligonucleotide based-biosensors for label-free electrochemical protein and dna detection<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Oligonucleotide based-biosensors for label-free electrochemical protein and dna detection <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00f3nica Mir Llorente <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Rovira i virgili<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ioanis Katakis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Rius ferr\u00fas  francesc xavier <\/li>\n<li>sotiris Kakabakos (vocal)<\/li>\n<li> Fern\u00e1ndez abedul  Mar\u00eda teresa (vocal)<\/li>\n<li>arben Merko\u00ed\u00a7i (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00f3nica Mir Llorente El trabajo hecho en esta tesis describe el desarrollo de nuevas plataformas de biosensores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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