{"id":55712,"date":"2018-03-09T22:43:26","date_gmt":"2018-03-09T22:43:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-cla%c2%adnica-e-inmunogenetica-de-la-enfermedad-de-addison\/"},"modified":"2018-03-09T22:43:26","modified_gmt":"2018-03-09T22:43:26","slug":"caracterizacion-cla%c2%adnica-e-inmunogenetica-de-la-enfermedad-de-addison","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/endocrinologia\/caracterizacion-cla%c2%adnica-e-inmunogenetica-de-la-enfermedad-de-addison\/","title":{"rendered":"Caracterizaci\u00f3n cl\u00ednica e inmunogen\u00e9tica de la enfermedad de addison"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Federico V\u00e1zquez San Miguel <\/strong><\/h2>\n<p>Introducci\u00f3n     la enfermedad de addison (ea) es una patolog\u00eda poco relevante, cuya cl\u00ednica es muy poco espec\u00edfica. La etiolog\u00eda autoinmune es la m\u00e1s frecuente actualmente. La ea de causa autoinmune puede aparecer aislada o asociada a s\u00edndromes poliglandulares autoinmunes, y se asocia a genes localizados en la regi\u00f3n hla. Recientemente se han descrito nuevos marcadores serol\u00f3gicos de autoinmunidad contra la adrenal, los anticuerpos anti-21 hidroxilasa (21ohac), m\u00e1s sensibles y espec\u00edficos que los marcadores previos. Adem\u00e1s los anticuerpos anti-17 hidroxilasa (17ohac) y anti-desmolasa (sccac) parecen ser indicadores de fallo gonadal asociado a la ea autoinmune.  objetivos     el objetivo del estudio ha sido evaluar la utilidad cl\u00ednica de la determinaci\u00f3n de los 21ohac para identificar a pacientes con ea autoinmune y determinar la existencia de enfermedades o marcadores de autoinmunidad organoespec\u00edfica. En los pacientes con ea autoinmune se ha valorado la asociaci\u00f3n con alelos del hal drb1.  material y m\u00e9todos     se ha estudiado 139 pacientes con ea de diferentes etiolog\u00edas y a 75 familiares, pertenecientes a 30 familias de pacientes con ea autoinmune. Inicialmente se realiz\u00f3 un estudio retrospectivo, recogiendo datos de las historias cl\u00ednicas, posteriormente se hizo un estudio transversal determinando mediante radioinmunoensayo los marcadores de autoinmunidad adrenal (21ohac, 17ohac, sccac) y contra el p\u00e1ncreas, el tiroides y la c\u00e9lula intestinal. Se ha estudiado la regi\u00f3n hla-drb1 mediante un an\u00e1lisis de hibridaci\u00f3n inversa.  resultados     la ea autoinmune ha sido la m\u00e1s frecuente en nuestra poblaci\u00f3n y en m\u00e1s de la mitad de los casos asociada a un s\u00edndrome poliglandular tipo 2. La alteraci\u00f3n tiroidea asociada ha sido la m\u00e1s frecuente, seguida del fallo ov\u00e1rico y la diabetes tipo 1. La presencia de fallo ov\u00e1rico se asocia a 17ohac y scca. El dr3 se asocia a riesgo y del dr7 a protecci\u00f3n en la ea autoinmune.  conc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n cl\u00ednica e inmunogen\u00e9tica de la enfermedad de addison<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n cl\u00ednica e inmunogen\u00e9tica de la enfermedad de addison <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Federico V\u00e1zquez San Miguel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Martul Tob\u00edo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Carlos Vitoria cormenzana <\/li>\n<li>daniel Solano p\u00e9rez (vocal)<\/li>\n<li>aniceto Luis Charro salgado (vocal)<\/li>\n<li> Luzuriaga tomas Mar\u00eda cristina (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Federico V\u00e1zquez San Miguel Introducci\u00f3n la enfermedad de addison (ea) es una patolog\u00eda poco relevante, cuya cl\u00ednica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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