{"id":55714,"date":"2018-03-09T22:43:26","date_gmt":"2018-03-09T22:43:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/reacciones-de-c-n-o-y-s-arilacion-catalizadas-por-paladio-y-cobre-en-medios-total-o-parcialmente-acuosos-sa%c2%adntesis-del-farmaco-oxcarbazepina-y-otros-compuestos-de-interes\/"},"modified":"2018-03-09T22:43:26","modified_gmt":"2018-03-09T22:43:26","slug":"reacciones-de-c-n-o-y-s-arilacion-catalizadas-por-paladio-y-cobre-en-medios-total-o-parcialmente-acuosos-sa%c2%adntesis-del-farmaco-oxcarbazepina-y-otros-compuestos-de-interes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-coordinados\/reacciones-de-c-n-o-y-s-arilacion-catalizadas-por-paladio-y-cobre-en-medios-total-o-parcialmente-acuosos-sa%c2%adntesis-del-farmaco-oxcarbazepina-y-otros-compuestos-de-interes\/","title":{"rendered":"Reacciones de c-, n-, o- y s-arilaci\u00f3n catalizadas por paladio y cobre en medios total o parcialmente acuosos. s\u00edntesis del f\u00e1rmaco oxcarbazepina y otros compuestos de inter\u00e9s"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00f3nica Carril Garc\u00eda <\/strong><\/h2>\n<p>En la primera parte se describe una nueva s\u00edntesis del f\u00e1rmaco antiepil\u00e9ptico oxarbazepina y su primera familia de an\u00e1logos. Los pasos claves en la preparaci\u00f3n de dicho f\u00e1rmaco consisten en reacciones de alfa-arilaci\u00f3n de enolatos y n-arilaci\u00f3n de aminas catalizadas por paladio en las que el agua, empleada como aditivo, ha tenido un papel destacado. Tras un proceso de optimizaci\u00f3n, la ruta sint\u00e9tica as\u00ed dise\u00f1ada ha permitido la preparaci\u00f3n de una serie de an\u00e1logos de la oxcarbazepina que adem\u00e1s han sido sometidos a evaluaci\u00f3n farmacol\u00f3gica.     en la segunda parte se describe un nuevo protocolo para llevar a cabo diversas reacciones de arilaci\u00f3n empleando cat\u00e1lisis de cobre en medios exclusivamente acuosas. As\u00ed,  por medio de una sal de cobre y un derivado de 1,2-diamina (actuando como oligando y como base) disueltos en agua ha sido posible la formaci\u00f3n de enlaces c(arilo)-o, c(arilo)-n y c(arilo)-s.     en este contexto, la reacci\u00f3n de o-arilaci\u00f3n intramolecular catalizada por cobre puesta a punto ha permitido el dise\u00f1o de una novedosa ruta para el acceso a distintos benzo[b]furanos. Por otro lado, tambi\u00e9n ha sido posible el acoplamiento intermolecular de tioles y haluros de airlo rindiendo los correspondientes diaril sulfuros, a trav\u00e9s de una reacci\u00f3n de s-arilaci\u00f3n catalizada por cobre. En ambas transformaciones ha sido posible la recuperaci\u00f3n y reutilizaci\u00f3n de la fase acuosa con el catalizador disuelto.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Reacciones de c-, n-, o- y s-arilaci\u00f3n catalizadas por paladio y cobre en medios total o parcialmente acuosos. s\u00edntesis del f\u00e1rmaco oxcarbazepina y otros compuestos de inter\u00e9s<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Reacciones de c-, n-, o- y s-arilaci\u00f3n catalizadas por paladio y cobre en medios total o parcialmente acuosos. s\u00edntesis del f\u00e1rmaco oxcarbazepina y otros compuestos de inter\u00e9s <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00f3nica Carril Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Esther Dominguez Perez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Miranda alonso <\/li>\n<li>Francisco Palacios gambra (vocal)<\/li>\n<li>Miguel \u00e1ngel Peric\u00ed\u00a0s brondo (vocal)<\/li>\n<li>roser Pleixats rovira (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00f3nica Carril Garc\u00eda En la primera parte se describe una nueva s\u00edntesis del f\u00e1rmaco antiepil\u00e9ptico oxarbazepina y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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