{"id":55731,"date":"2018-03-09T22:43:26","date_gmt":"2018-03-09T22:43:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-papel-de-la-cardiotrofina-1-ct-1-en-el-dano-hepatico-por-isquemia-reperfusion\/"},"modified":"2018-03-09T22:43:26","modified_gmt":"2018-03-09T22:43:26","slug":"caracterizacion-del-papel-de-la-cardiotrofina-1-ct-1-en-el-dano-hepatico-por-isquemia-reperfusion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/gastroenterologia\/caracterizacion-del-papel-de-la-cardiotrofina-1-ct-1-en-el-dano-hepatico-por-isquemia-reperfusion\/","title":{"rendered":"Caracterizacion del papel de la cardiotrofina 1 (ct-1) en el da\u00f1o hepatico por isquemia reperfusion"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda I\u00f1iguez Martinez <\/strong><\/h2>\n<p>Ischemia\/reperfusion (i\/r) liver injury occurs when blood flow is restored after prolonged ischemia. A short interruption of blood flow (ischetnic preconditioning, ip) induces tolerance to subsequent prolonged ischemia through ill defined mechanisms. Cardiotrophin-1 (ct-1), a cytokine of the interleukin-6 (il-6) family, exerts hepatoprotective effects and activates key survival pathways like jak\/stat3. Here we show that administration of ct-1 to rats or mice protects against i\/r liver injury and that ct-l-deficient mice are exceedingly sensitive to this type of damage. Ip markedly reduced transaminase lev\u00e9is and abrogated caspase-3 and c-jun-nh2-terminal kinase activation after i\/r in normal mice but not in ct-l-null mice. Moreover, the protective effect afforded by ip was reduced by previous administration of neutralizing anti-ct-1 antibody. Prominent stat3 phosphorylation in liver tissue was observed after ip plus i\/r in normal mice but not in ct-l-null mice. Oxidative stress, a process involved in ip-induced hepatoprotection, was found to stimulate ct-1 rel\u00e9ase from isolated hepatocytes. Interestingly, brief ischemia followed by short reperfusion caused mild serum transaminase elevation and strong stat3 activation in normal mice, but failed to activate stat3 and provoked marked hypertransaminasemia in ct-l-null animals. In conclusi\u00f3n, ct-1 is an essential endogenous defense of the liver against i\/r and is a key mediator of the protective effect induced by ip.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion del papel de la cardiotrofina 1 (ct-1) en el da\u00f1o hepatico por isquemia reperfusion<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion del papel de la cardiotrofina 1 (ct-1) en el da\u00f1o hepatico por isquemia reperfusion <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda I\u00f1iguez Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas M. Prieto Valtue\u00f1a<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joan Caballeria rovira <\/li>\n<li>Mar\u00eda Jos\u00e9 Iraburu elizalde (vocal)<\/li>\n<li>pablo Ortiz betes (vocal)<\/li>\n<li>ramon Bataller alberola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda I\u00f1iguez Martinez Ischemia\/reperfusion (i\/r) liver injury occurs when blood flow is restored after prolonged ischemia. A [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,36483,1279,491,17749],"tags":[15059,33878,123118,41611,25726,123119],"class_list":["post-55731","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-biologia-molecular","category-cirugia-experimental","category-gastroenterologia","category-navarra","tag-jesus-m-prieto-valtuena","tag-joan-caballeria-rovira","tag-maria-iniguez-Martinez","tag-maria-jose-iraburu-elizalde","tag-pablo-ortiz-betes","tag-ramon-bataller-alberola"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=55731"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55731\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=55731"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=55731"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=55731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}