{"id":55771,"date":"2018-03-09T22:43:30","date_gmt":"2018-03-09T22:43:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-s-ibuprofeno-sobre-el-funcionalismo-plaquetario-en-el-ser-humano-comparacion-con-dosis-bajas-de-acido-acetilsalica%c2%adlico\/"},"modified":"2018-03-09T22:43:30","modified_gmt":"2018-03-09T22:43:30","slug":"efectos-de-s-ibuprofeno-sobre-el-funcionalismo-plaquetario-en-el-ser-humano-comparacion-con-dosis-bajas-de-acido-acetilsalica%c2%adlico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/accion-de-los-farmacos\/efectos-de-s-ibuprofeno-sobre-el-funcionalismo-plaquetario-en-el-ser-humano-comparacion-con-dosis-bajas-de-acido-acetilsalica%c2%adlico\/","title":{"rendered":"Efectos de s(+)-ibuprofeno sobre el funcionalismo plaquetario en el ser humano: comparaci\u00f3n con dosis bajas de \u00e1cido acetilsalic\u00edlico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva Mart\u00edn Salido <\/strong><\/h2>\n<p>Los pacientes que toman cr\u00f3nicamente un agente antiagregante plaquetario y se interrumpe dicho tratamiento, presentan una mayor incidencia de accidentes isqu\u00e9micos, a modo de un \u00abefecto rebote\u00bb. Para evitar esta desprotecci\u00f3n, una alternativa ser\u00eda la administraci\u00f3n de un f\u00e1rmaco anti-inflamatorio no esteroideo (nsaid), que inhiba la funci\u00f3n plaquetaria de forma reversible durante los d\u00edas en los que el paciente no toma aspirina.  el objetivo del estudio fue valorar el efecto antiagregante planetario de dexibuprofeno en voluntarios sanos, en comparaci\u00f3n con aspirina dosis usadas en la profilaxis de la trombosis. Doce voluntarios se dividieron en dos grupos: uno recibi\u00f3 100 mg\/d\u00eda de aspirina y otro 400&#215;2 mg\/d\u00eda de dexibuprofeno. Las muestras de sangre se obtuvieron antes y tras 1,2,4,8,12 y 24 horas de la primera toma 3 y 7 d\u00edas tras la ingesta diaria y a las 24h de la \u00faltima toma. se cuantificaron las siguientes variables: agregometr\u00eda plaquetaria, s\u00edntesis de tromboxano (cox-1), de prostaglandina e2 (cox-2), prostaciclina y \u00f3xido n\u00edtrico, estos dos \u00faltimos inducidos por v\u00eda constitutiva y por v\u00eda inducible. en todos los casos, el efecto antiplaquetario de dexibuprofeno fue igual al obtenido con aspirina, tanto tras una dosis \u00fanica como en el tratamiento de 14 d\u00edas. la principal diferencia entre ambos f\u00e1rmacos fue el grado de recuperaci\u00f3n de la funci\u00f3n plaquetaria y que mientras que aspirina manten\u00eda su efecto 24 horas tras la \u00fanica dosis o tras la \u00faltima dosis en el d\u00eda 15, los voluntarios que tomaron dexibuprofeno mostraron unos valores plaquetarios iguales a los basales pre-tratamiento. Como principal conclusi\u00f3n se podr\u00eda decir que dexibuprofeno podr\u00eda ser una alternativa al uso de aspirina en los periodos de retirada de este f\u00e1rmaco en personas que lo toman cr\u00f3nicamente como profilaxis del fen\u00f3meno tromb\u00f3tico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de s(+)-ibuprofeno sobre el funcionalismo plaquetario en el ser humano: comparaci\u00f3n con dosis bajas de \u00e1cido acetilsalic\u00edlico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de s(+)-ibuprofeno sobre el funcionalismo plaquetario en el ser humano: comparaci\u00f3n con dosis bajas de \u00e1cido acetilsalic\u00edlico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva Mart\u00edn Salido <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/11\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Pedro De La Cruz Cort\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rosario Calvo duo <\/li>\n<li>Miguel Such mart\u00ednez (vocal)<\/li>\n<li>Elena Su\u00e1rez gonz\u00e1lez (vocal)<\/li>\n<li>maximino Redondo bautita (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva Mart\u00edn Salido Los pacientes que toman cr\u00f3nicamente un agente antiagregante plaquetario y se interrumpe dicho tratamiento, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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