{"id":55842,"date":"2006-01-12T00:00:00","date_gmt":"2006-01-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/senalizacion-por-receptores-de-cannabinoides-en-los-terminales-glutamatergicos-de-corteza-cerebral\/"},"modified":"2006-01-12T00:00:00","modified_gmt":"2006-01-12T00:00:00","slug":"senalizacion-por-receptores-de-cannabinoides-en-los-terminales-glutamatergicos-de-corteza-cerebral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/senalizacion-por-receptores-de-cannabinoides-en-los-terminales-glutamatergicos-de-corteza-cerebral\/","title":{"rendered":"Se\u00f1alizaci\u00f3n por receptores de cannabinoides en los terminales glutamat\u00e9rgicos de corteza cerebral."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Godino Alarc\u00f3n M\u00aa Carmen <\/strong><\/h2>\n<p>La transmisi\u00f3n sin\u00e1ptica glutamat\u00e9rgica est\u00e1 regulada por los endocannabinoides que se  sintetizan en respuesta a la despolarizaci\u00f3n de la c\u00e9lula postsin\u00e1ptica. Estas sustancias lipof\u00edlicas son liberadas desde la c\u00e9lula postsin\u00e1ptica alcanzando los terminales sin\u00e1pticos donde inhiben laliberaci\u00f3n de neurotransmisor. Si bien la activaci\u00f3n de los receptores de cannabinoides pone en marcha distintas vias de se\u00f1alizaci\u00f3n, se desconoce el sistema de transducci\u00f3n de se\u00f1ales presin\u00e1ptico responsable de la inhibici\u00f3n de la exocitosis de glutamato.  en preparaciones de terminales sin\u00e1pticos (sinaptosomas) de corteza cerebral de rata hemos determinado los cambios producidos por los endocannabinoides en las concentraciones de segundos mensajeros y en la liberaci\u00f3n de glutamato. Los datos obtenidos muestran que el agonista win55,212-2 reduce la liberaci\u00f3n de glutamato inducida por la despolarizaci\u00f3n de la membrana plasm\u00e1tica. Esta acci\u00f3n inhibidora, es revertida por el antagonista sr-141716, tiene lugar en ausencia de cambios de ampc y conlleva una reducci\u00f3n en la entrada de calcio en el terminal sin\u00e1ptico, lo que sugiere la inhibici\u00f3n directa de la actividad de los canales de calcio acoplados a la exocitosis de glutamato. El agonista cannabinoide no modific\u00f3 los niveles de ampc por lo que cabe pensar que la inhibici\u00f3n de la liberaci\u00f3n inducida por 4-ap no resulta de una reducci\u00f3n de los niveles de ampc. Sin embargo, la activaci\u00f3n de la adenilato ciclasa con forskolina o con el agonista de receptores beta-adren\u00e9rgicos isoproterenol increment\u00f3 los niveles de ampc y la liberaci\u00f3n espont\u00e1nea de glutamato y ambas respuestas fueron reducidas por el agonista cannabinoide win55,212-2. Ahora bien, dado que el agonista cannabinoide redujo tambi\u00e9n la liberaci\u00f3n en presencia del an\u00e1logo de ampc sp-8-br-camps, que activa directamente la pka sin modificar los niveles de ampc end\u00f3genos, cabe pensar que la inhibici\u00f3n de laliberaci\u00f3n espont\u00e1nea pro<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Se\u00f1alizaci\u00f3n por receptores de cannabinoides en los terminales glutamat\u00e9rgicos de corteza cerebral.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Se\u00f1alizaci\u00f3n por receptores de cannabinoides en los terminales glutamat\u00e9rgicos de corteza cerebral. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Godino Alarc\u00f3n M\u00aa Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>prieto Borja S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Guzm\u00e1n Pastor <\/li>\n<li> L\u00f3pez De Ceballos Lafarga Mar\u00eda (vocal)<\/li>\n<li> Sol\u00eds Torralba Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Beatriz L\u00f3pez Corcuera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Godino Alarc\u00f3n M\u00aa Carmen La transmisi\u00f3n sin\u00e1ptica glutamat\u00e9rgica est\u00e1 regulada por los endocannabinoides que se sintetizan en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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