{"id":55864,"date":"2006-04-12T00:00:00","date_gmt":"2006-04-12T00:00:00","guid":{"rendered":""},"modified":"2006-04-12T00:00:00","modified_gmt":"2006-04-12T00:00:00","slug":"aplicacion-de-la-cromatografa%c2%ada-la%c2%adquida-acoplada-a-la-espectrometria-de-masas-simple-y-en-tandem-a-la-determinacion-de-derivados-anfetama%c2%adnicos-y-otras-drogas-de-abuso-en-medios-biolog","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/medicina-forense\/aplicacion-de-la-cromatografa%c2%ada-la%c2%adquida-acoplada-a-la-espectrometria-de-masas-simple-y-en-tandem-a-la-determinacion-de-derivados-anfetama%c2%adnicos-y-otras-drogas-de-abuso-en-medios-biolog\/","title":{"rendered":"Aplicaci\u00f3n de la cromatograf\u00edal\u00edquida acoplada a la espectrometr\u00eda de masas simple y en tandem a la determinaci\u00f3n de derivados anfetam\u00ednicos y otras drogas de abuso en medios biol\u00f3gicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Concheiro Guis\u00e1n <\/strong><\/h2>\n<p>El objetivo de esta memoria, que constituye la tesis doctoral, ha sido el desarrollo de m\u00e9todos de determinaci\u00f3n de derivados anfetam\u00ednicos y otras drogas de abuso, como la coca\u00edna y los opi\u00e1ceos, en matrices biol\u00f3gicas, que permitan una adecuada interpretaci\u00f3n de la situaci\u00f3n en que se enmarcan los casos de car\u00e1cter m\u00e9dico-legal. Se ha utilizado la t\u00e9cnica cromatograf\u00eda l\u00edquida acoplada a la espectrometr\u00eda de masas simple o en tandem, aplic\u00e1ndola a casos reales, y prestando especial atenci\u00f3n a las muertes por accidentes de tr\u00e1fico, y a las muertes de significaci\u00f3n m\u00e9dico-legal relacionadas con el consumo de los derivados anfetam\u00ednicos. se han desarrollado y validado completamente cuatro m\u00e9todos anal\u00edticos distintos. Uno de ellos permit\u00eda la determinaci\u00f3n simult\u00e1nea de la anfetamina, la metanfetamina, la mda, la mdma, la mdea, la mbdb, la morfina, la 6-monoacetilmorfina, la coca\u00edna y la benzoilecgonina, en 0.2 ml de plasma, llegando a un l\u00edmite de cuantificaci\u00f3n de 2 ng\/ml, aplicando una extracci\u00f3n en fase s\u00f3lida automatizada, y una separaci\u00f3n cromatogr\u00e1fica en fase reversa. Los otros tres, orientados a los derivados anfetam\u00ednicos, permitieron la determinaci\u00f3n simult\u00e1nea de la anfetamina, la metanfetamina, la mda, la pma, la mdma, la mdea y la mbdb, en muestras de sangre, orina e h\u00edgado, empleando 0.5 ml o 1 g de muestra biol\u00f3gica, obteniendo unos l\u00edmites de cuantificaci\u00f3n comprendidos entre 1 y 2 ng\/ml, y de 8 ng\/g, respectivamente. La extracci\u00f3n utilizada en estos tres casos, fue l\u00edquido-l\u00edquido usando dietil\u00e9ter a ph b\u00e1sico, y la separaci\u00f3n cromatogr\u00e1fica tambi\u00e9n fue realizada en fase reversa. el m\u00e9todo de determinaci\u00f3n de anfetaminas, opi\u00e1ceos y coca\u00edna en plasma, fue aplicado a muestras cl\u00ednico\/judiciales y a casos de muertes en accidentes de tr\u00e1fico, remitidas al servicio de toxicolog\u00eda del instituto universitario de medicina legal de santiago de compostela, encontr\u00e1ndose alguna de las drogas de abuso in<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicaci\u00f3n de la cromatograf\u00edal\u00edquida acoplada a la espectrometr\u00eda de masas simple y en tandem a la determinaci\u00f3n de derivados anfetam\u00ednicos y otras drogas de abuso en medios biol\u00f3gicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicaci\u00f3n de la cromatograf\u00edal\u00edquida acoplada a la espectrometr\u00eda de masas simple y en tandem a la determinaci\u00f3n de derivados anfetam\u00ednicos y otras drogas de abuso en medios biol\u00f3gicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Concheiro Guis\u00e1n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angelines Cruz Landeira<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Villanueva ca\u00f1ada <\/li>\n<li>\u00f3scar Quintela Jorge (vocal)<\/li>\n<li>david Ordo\u00f1ez escudero (vocal)<\/li>\n<li>alain Verstraete (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Concheiro Guis\u00e1n El objetivo de esta memoria, que constituye la tesis doctoral, ha sido el desarrollo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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